HitPredict

Interactor 1: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Interactor 2: CDC6 (Q99741)
Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6)
Gene: CDC6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	10464337, 15232106
Identification Methods	affinity chromatography technology, pull down, protein array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006270 - DNA replication initiation GO:0016887 - ATP hydrolysis activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 808 Hs			1 560
+	Hs
		832668 MCM2_HUMAN (10-721): 0: 707: 30.62		CDC6_HUMAN (1-560): 1.83e-166: 486: 100.00
+	Hs
		708744 MCM5_HUMAN (9-713): 0: 685: 28.92		CDC6_HUMAN (1-560): 1.83e-166: 486: 100.00
+	Hs
		217775 MCM3_HUMAN (1-808): 0: 944: 100.00		ORC4_HUMAN (143-552): 5.24e-66: 222: 14.49
+	Hs
		709020 MCM7_HUMAN (10-669): 0: 650: 31.62		CDC6_HUMAN (1-560): 1.83e-166: 486: 100.00
+	Hs
		832428 MCM2_HUMAN (10-721): 0: 707: 30.62		ORC1_HUMAN (4-548): 3.74e-94: 308: 22.62
+	Hs
		1033381 MCM6_HUMAN (2-800): 0: 688: 26.50		ORC1_HUMAN (4-548): 3.74e-94: 308: 22.62
+	Hs
		708627 MCM5_HUMAN (9-713): 0: 685: 28.92		ORC1_HUMAN (4-548): 3.74e-94: 308: 22.62
+	Hs
		708434 MCM4_HUMAN (9-739): 0: 661: 28.03		ORC1_HUMAN (4-548): 3.74e-94: 308: 22.62
+	Hs
		708888 MCM7_HUMAN (10-669): 0: 650: 31.62		ORC1_HUMAN (4-548): 3.74e-94: 308: 22.62
+	Hs
		217789 MCM2_HUMAN (10-721): 0: 707: 30.62		ORC4_HUMAN (143-552): 5.24e-66: 222: 14.49
+	Hs
		217802 MCM6_HUMAN (2-800): 0: 688: 26.50		ORC4_HUMAN (143-552): 5.24e-66: 222: 14.49
+	Sc
		667613 MCM2_YEAST (6-668): 0: 664: 32.15		ORC1_YEAST (49-554): 6.6e-69: 240: 19.74
+	Sc
		622184 MCM3_YEAST (45-782): 0: 655: 44.49		ORC1_YEAST (49-554): 6.6e-69: 240: 19.74
+	Sc
		675544 MCM4_YEAST (9-804): 0: 654: 27.82		ORC1_YEAST (49-554): 6.6e-69: 240: 19.74
+	Hs
		217779 MCM4_HUMAN (9-739): 0: 661: 28.03		ORC4_HUMAN (143-552): 5.24e-66: 222: 14.49
+	Sc
		447785 MCM2_YEAST (6-668): 0: 664: 32.15		CDC6_YEAST (82-521): 6.22e-61: 211: 24.54
+	Hs
		217780 MCM7_HUMAN (10-669): 0: 650: 31.62		ORC4_HUMAN (143-552): 5.24e-66: 222: 14.49
+	Sc
		447782 MCM3_YEAST (45-782): 0: 655: 44.49		CDC6_YEAST (82-521): 6.22e-61: 211: 24.54
+	Sc
		744785 MCM7_YEAST (20-674): 8.95e-91: 305: 34.27		ORC1_YEAST (49-554): 6.6e-69: 240: 19.74
+	Sc
		447792 MCM7_YEAST (20-674): 8.95e-91: 305: 34.27		CDC6_YEAST (82-521): 6.22e-61: 211: 24.54