HitPredict

Interactor 1: CD9 (P21926)
CD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9)
Gene: CD9

Interactor 2: IGSF8 (Q969P0)
Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)
Gene: IGSF8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.962

Property	Details
Experiments	30833792, 11504738, 26186194, 28514442, 33961781, 26686862, 23289620
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Tetraspanin~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 228 Hs			1 613
+	Hs
		967334 TSN5_HUMAN (7-225): 2.56e-54: 176: 23.64		IGSF8_HUMAN (1-613): 8.33e-173: 506: 100.00
+	Hs
		948902 CD81_HUMAN (1-225): 3.29e-54: 175: 43.59		IGSF8_HUMAN (1-613): 8.33e-173: 506: 100.00
+	Mm
		776905 CD81_MOUSE (1-225): 3.22e-52: 170: 44.87		IGSF8_MOUSE (22-613): 2.13e-171: 502: 90.20
+	Hs
		697359 CD82_HUMAN (4-224): 1.08e-46: 157: 24.23		IGSF8_HUMAN (1-613): 8.33e-173: 506: 100.00
+	Hs
		252619 TSN2_HUMAN (3-228): 5.69e-45: 151: 46.46		IGSF8_HUMAN (1-613): 8.33e-173: 506: 100.00
+	Hs
		641987 CD9_HUMAN (1-228): 1.14e-61: 194: 100.00		FPRP_HUMAN (37-604): 5.77e-51: 191: 19.90
+	Hs
		967365 TSN5_HUMAN (7-225): 2.56e-54: 176: 23.64		FPRP_HUMAN (37-604): 5.77e-51: 191: 19.90
+	Hs
		948953 CD81_HUMAN (1-225): 3.29e-54: 175: 43.59		FPRP_HUMAN (37-604): 5.77e-51: 191: 19.90
+	Hs
		477478 CD63_HUMAN (1-228): 5.97e-53: 172: 24.49		FPRP_HUMAN (37-604): 5.77e-51: 191: 19.90
+	Hs
		1339815 TSN14_HUMAN (11-225): 2.71e-50: 166: 24.02		FPRP_HUMAN (37-604): 5.77e-51: 191: 19.90
+	Hs
		873796 CD151_HUMAN (3-222): 7.64e-50: 164: 30.08		FPRP_HUMAN (37-604): 5.77e-51: 191: 19.90
+	Hs
		697368 CD82_HUMAN (4-224): 1.08e-46: 157: 24.23		FPRP_HUMAN (37-604): 5.77e-51: 191: 19.90
+	Hs
		252640 TSN2_HUMAN (3-228): 5.69e-45: 151: 46.46		FPRP_HUMAN (37-604): 5.77e-51: 191: 19.90
+	Hs
		641994 CD9_HUMAN (1-228): 1.14e-61: 194: 100.00		ROBO1_HUMAN (25-507): 1.96e-32: 136: 12.83
+	Hs
		948980 CD81_HUMAN (1-225): 3.29e-54: 175: 43.59		ROBO1_HUMAN (25-507): 1.96e-32: 136: 12.83
+	Hs
		269835 CD9_HUMAN (1-228): 1.14e-61: 194: 100.00		IGSF3_HUMAN (19-305): 3.9e-20: 97.2: 17.89
+	Hs
		269850 TSN5_HUMAN (7-225): 2.56e-54: 176: 23.64		IGSF3_HUMAN (19-305): 3.9e-20: 97.2: 17.89
+	Hs
		269877 TSN14_HUMAN (11-225): 2.71e-50: 166: 24.02		IGSF3_HUMAN (19-305): 3.9e-20: 97.2: 17.89
+	Hs
		269820 TSN15_HUMAN (10-222): 6.1e-43: 148: 15.66		IGSF3_HUMAN (19-305): 3.9e-20: 97.2: 17.89
+	Hs
		1288409 TSN33_HUMAN (10-224): 1.6e-49: 164: 20.08		TITIN_HUMAN (4-593): 4.91e-11: 68.3: 8.89