Protein: IGSF8
Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)

Gene: IGSF8
Organism: Homo sapiens
Interactions: 245
UniProt ID: Q969P0

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0007338 - single fertilization
GO:0007399 - nervous system development
GO:0007519 - skeletal muscle tissue development
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

641970

CD9
CD9 antigen

7

20

Small-scale

0.962

High

999671

HBA
Hemoglobin subunit alpha

3

2

High-throughput

0.861

High

1335563

DGLB
Diacylglycerol lipase-beta

4

0

High-throughput

0.846

High

948902

CD81
CD81 antigen

3

20

Small-scale

0.839

High

349521

TSN15
Tetraspanin-15

2

20

High-throughput

0.776

High

1380606

CLC4A
C-type lectin domain family 4 member A

2

6

High-throughput

0.776

High

1380590

TMX1
Thioredoxin-related transmembrane protein 1

3

10

High-throughput

0.765

High

652381

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

0

High-throughput

0.742

High

1098197

MMRN1
Multimerin-1

2

7

High-throughput

0.726

High

1380588

TMX4
Thioredoxin-related transmembrane protein 4

2

10

High-throughput

0.726

High

380468

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

3

High-throughput

0.691

High

596514

CTLA4
Cytotoxic T-lymphocyte protein 4

1

1

High-throughput

0.691

High

993437

ACTH
Actin, gamma-enteric smooth muscle

1

5

High-throughput

0.691

High

1119421

CAYP1
Calcyphosin

1

2

High-throughput

0.691

High

1329237

CLD19
Claudin-19

1

1

High-throughput

0.691

High

1352034

IGDC4
Immunoglobulin superfamily DCC subclass member 4

1

11

High-throughput

0.691

High

1380615

ST14
Suppressor of tumorigenicity 14 protein

1

5

High-throughput

0.691

High

1251337

DJC14
DnaJ homolog subfamily C member 14

4

5

High-throughput

0.691

High

1159792

OCLN
Occludin

3

2

High-throughput

0.667

High

1355916

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

3

1

High-throughput

0.662

High

1228767

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

3

0

High-throughput

0.638

High

1153476

EFNB3
Ephrin-B3

2

1

High-throughput

0.628

High

1187211

CC50B
Cell cycle control protein 50B

2

2

High-throughput

0.628

High

369723

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.621

High

131491

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

3

High-throughput

0.618

High

697359

CD82
CD82 antigen

1

20

Small-scale

0.618

High

141606

DDX3X
ATP-dependent RNA helicase DDX3X

1

7

High-throughput

0.618

High

188017

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

5

High-throughput

0.618

High

193135

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

7

High-throughput

0.618

High

422795

A4
Amyloid-beta precursor protein

1

10

Small-scale

0.618

High

555736

ACTN1
Alpha-actinin-1

1

10

High-throughput

0.618

High

608692

DDX5
Probable ATP-dependent RNA helicase DDX5

1

8

High-throughput

0.618

High

728369

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

High-throughput

0.618

High

773771

ACTN2
Alpha-actinin-2

1

10

High-throughput

0.618

High

882076

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.618

High

899513

TCPD
T-complex protein 1 subunit delta

1

3

High-throughput

0.618

High

946851

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.618

High

980989

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

997920

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.618

High

998646

H31
Histone H3.1

1

7

High-throughput

0.618

High

1017087

H33
Histone H3.3

1

7

High-throughput

0.618

High

1142353

PDIA6
Protein disulfide-isomerase A6

1

8

High-throughput

0.618

High

1161985

H31T
Histone H3.1t

1

7

High-throughput

0.618

High

1208867

H2B2F
Histone H2B type 2-F

1

20

High-throughput

0.618

High

1241724

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.618

High

1258905

H32
Histone H3.2

1

7

High-throughput

0.618

High

1369338

DDX17
Probable ATP-dependent RNA helicase DDX17

1

8

High-throughput

0.618

High

1372255

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.618

High

1380580

H2B1N
Histone H2B type 1-N

1

20

High-throughput

0.618

High

1380581

H2B1M
Histone H2B type 1-M

1

20

High-throughput

0.618

High

1380582

H2B1L
Histone H2B type 1-L

1

20

High-throughput

0.618

High

1380586

ACE2
Angiotensin-converting enzyme 2

1

3

Small-scale

0.618

High

1380600

IBTK
Inhibitor of Bruton tyrosine kinase

1

6

High-throughput

0.618

High

950358

KR107
Keratin-associated protein 10-7

3

8

High-throughput

0.616

High

950614

KR108
Keratin-associated protein 10-8

3

10

High-throughput

0.616

High

1081609

DYH14
Dynein axonemal heavy chain 14

3

2

High-throughput

0.609

High

583976

CD19
B-lymphocyte antigen CD19

2

0

High-throughput

0.602

High

170910

CLGN
Calmegin

2

6

High-throughput

0.601

High

1095920

EI2BE
Translation initiation factor eIF2B subunit epsilon

3

2

High-throughput

0.593

High

895499

SPB9
Serpin B9

1

0

High-throughput

0.586

High

1380589

GHITM
Growth hormone-inducible transmembrane protein

2

0

High-throughput

0.576

High

1380601

NCDN
Neurochondrin

2

0

High-throughput

0.576

High

161069

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

2

High-throughput

0.575

High

252619

TSN2
Tetraspanin-2

1

20

High-throughput

0.575

High

946086

ANTR2
Anthrax toxin receptor 2

1

1

High-throughput

0.575

High

967334

TSN5
Tetraspanin-5

1

20

High-throughput

0.575

High

1380605

FZD10
Frizzled-10

1

1

High-throughput

0.575

High

1277346

NT2NA
Notch homolog 2 N-terminal-like protein A

1

9

High-throughput

0.555

High

1059710

KRA11
Keratin-associated protein 1-1

2

10

High-throughput

0.553

High

1235802

KRA57
Keratin-associated protein 5-7

2

9

High-throughput

0.553

High

1307431

KRA13
Keratin-associated protein 1-3

2

10

High-throughput

0.553

High

207613

DHX15
ATP-dependent RNA helicase DHX15

1

6

High-throughput

0.553

High

256945

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.553

High

380770

HBD
Hemoglobin subunit delta

1

2

High-throughput

0.553

High

449769

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.553

High

613129

EGR1
Early growth response protein 1

1

2

Small-scale

0.553

High

659929

H2B1O
Histone H2B type 1-O

1

20

High-throughput

0.553

High

754935

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.553

High

1066430

RBBP4
Histone-binding protein RBBP4

1

4

High-throughput

0.553

High

1254939

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.553

High

1380576

H2B1A
Histone H2B type 1-A

1

20

High-throughput

0.553

High

530182

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.536

High

896846

DYN2
Dynamin-2

1

3

High-throughput

0.536

High

931424

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

2

High-throughput

0.536

High

1053823

KDSR
3-ketodihydrosphingosine reductase

1

1

High-throughput

0.536

High

1380596

CC50A
Cell cycle control protein 50A

1

2

High-throughput

0.536

High

950855

KR109
Keratin-associated protein 10-9

1

8

High-throughput

0.523

High

890151

EI2BB
Translation initiation factor eIF2B subunit beta

2

2

High-throughput

0.521

High

165635

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.513

High

1315974

NRSN1
Neurensin-1

1

0

High-throughput

0.513

High

1380611

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.513

High

871793

RFX3
Transcription factor RFX3

1

1

High-throughput

0.489

High

218590

TGON2
Trans-Golgi network integral membrane protein 2

1

11

High-throughput

0.479

High

224774

ACTN4
Alpha-actinin-4

1

10

High-throughput

0.479

High

250751

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

6

High-throughput

0.479

High

391388

FRIL
Ferritin light chain

1

2

High-throughput

0.479

High

391647

FRIH
Ferritin heavy chain

1

2

High-throughput

0.479

High

408124

TBB4A
Tubulin beta-4A chain

1

7

High-throughput

0.479

High

418331

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

428896

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.479

High

447285

NPM
Nucleophosmin

1

3

High-throughput

0.479

High

457602

TBB5
Tubulin beta chain

1

7

High-throughput

0.479

High

485315

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

18

High-throughput

0.479

High

535948

MYH3
Myosin-3

1

3

High-throughput

0.479

High

550399

PABP1
Polyadenylate-binding protein 1

1

6

High-throughput

0.479

High

558313

XRCC6
X-ray repair cross-complementing protein 6

1

5

High-throughput

0.479

High

559444

XRCC5
X-ray repair cross-complementing protein 5

1

5

High-throughput

0.479

High

573196

KPYM
Pyruvate kinase PKM

1

1

High-throughput

0.479

High

586814

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

620509

NUCL
Nucleolin

1

6

High-throughput

0.479

High

637670

FLNA
Filamin-A

1

17

High-throughput

0.479

High

644205

RS4Y1
Small ribosomal subunit protein eS4, Y isoform 1

1

2

High-throughput

0.479

High

650893

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

16

High-throughput

0.479

High

660134

COF1
Cofilin-1

1

1

High-throughput

0.479

High

683880

MOES
Moesin

1

5

High-throughput

0.479

High

686323

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.479

High

688096

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.479

High

716929

RL12
Large ribosomal subunit protein uL11

1

2

High-throughput

0.479

High

729390

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

16

High-throughput

0.479

High

756000

MCM5
DNA replication licensing factor MCM5

1

7

High-throughput

0.479

High

809764

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.479

High

824273

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.479

High

859383

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.479

High

860302

RS9
Small ribosomal subunit protein uS4

1

2

High-throughput

0.479

High

910621

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

6

High-throughput

0.479

High

939402

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

4

High-throughput

0.479

High

942799

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

9

High-throughput

0.479

High

959894

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

960195

RL26
Large ribosomal subunit protein uL24

1

4

High-throughput

0.479

High

961357

RL27
Large ribosomal subunit protein eL27

1

2

High-throughput

0.479

High

965814

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

9

High-throughput

0.479

High

969349

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.479

High

975847

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.479

High

977322

RS4X
Small ribosomal subunit protein eS4, X isoform

1

2

High-throughput

0.479

High

978645

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

979118

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

985800

RL11
Large ribosomal subunit protein uL5

1

1

High-throughput

0.479

High

986135

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.479

High

994702

YBOX1
Y-box-binding protein 1

1

3

High-throughput

0.479

High

997069

TBA4A
Tubulin alpha-4A chain

1

9

High-throughput

0.479

High

1016143

RL19
Large ribosomal subunit protein eL19

1

1

High-throughput

0.479

High

1027646

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

8

High-throughput

0.479

High

1039318

RL6
Large ribosomal subunit protein eL6

1

1

High-throughput

0.479

High

1057839

RL18
Large ribosomal subunit protein eL18

1

1

High-throughput

0.479

High

1089497

ILF2
Interleukin enhancer-binding factor 2

1

5

High-throughput

0.479

High

1089786

ILF3
Interleukin enhancer-binding factor 3

1

8

High-throughput

0.479

High

1102883

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

7

High-throughput

0.479

High

1121841

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

9

High-throughput

0.479

High

1125378

FLNC
Filamin-C

1

20

High-throughput

0.479

High

1126501

CAPR1
Caprin-1

1

5

High-throughput

0.479

High

1146963

PCBP2
Poly(rC)-binding protein 2

1

8

High-throughput

0.479

High

1161590

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

1249083

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

1259399

TBA1A
Tubulin alpha-1A chain

1

9

High-throughput

0.479

High

1290101

THOC4
THO complex subunit 4

1

8

High-throughput

0.479

High

1366734

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

6

High-throughput

0.479

High

1380578

VPS35
Vacuolar protein sorting-associated protein 35

1

2

High-throughput

0.479

High

1380585

TBB6
Tubulin beta-6 chain

1

7

High-throughput

0.479

High

1380607

RL26L
Ribosomal protein uL24-like

1

4

High-throughput

0.479

High

1380608

DYN3
Dynamin-3

1

3

High-throughput

0.479

High

1380610

COF2
Cofilin-2

1

1

High-throughput

0.479

High

1380613

RL36
Large ribosomal subunit protein eL36

1

1

High-throughput

0.479

High

950221

KR104
Keratin-associated protein 10-4

1

8

High-throughput

0.470

High

1380587

KRA24
Keratin-associated protein 2-4

1

9

High-throughput

0.470

High

428469

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.458

High

611938

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.458

High

658321

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

749094

RL9
Large ribosomal subunit protein uL6

1

0

High-throughput

0.458

High

770249

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.458

High

785346

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

842471

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.458

High

859014

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.458

High

949415

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.458

High

970018

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.458

High

972506

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.458

High

972740

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.458

High

972927

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.458

High

973255

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

982506

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

983014

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.458

High

983325

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

984486

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

984887

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1013831

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.458

High

1025734

PURA
Transcriptional activator protein Pur-alpha

1

0

High-throughput

0.458

High

1380602

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.458

High

1380609

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.458

High

271733

HIP1R
Huntingtin-interacting protein 1-related protein

1

5

High-throughput

0.445

High

651094

RFX1
MHC class II regulatory factor RFX1

1

4

High-throughput

0.445

High

1124217

EI2BA
Translation initiation factor eIF2B subunit alpha

1

2

High-throughput

0.445

High

597

NBPFJ
NBPF family member NBPF19

1

4

High-throughput

0.439

High

505367

KRA23
Keratin-associated protein 2-3

1

9

High-throughput

0.439

High

949960

KR103
Keratin-associated protein 10-3

1

10

High-throughput

0.439

High

1380583

KR412
Keratin-associated protein 4-12

1

10

High-throughput

0.439

High

81728

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

1

High-throughput

0.437

High

106412

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

295221

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

5

High-throughput

0.437

High

485702

RU2A
U2 small nuclear ribonucleoprotein A'

1

6

High-throughput

0.437

High

521845

H14
Histone H1.4

1

9

High-throughput

0.437

High

574407

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

2

High-throughput

0.437

High

595838

H13
Histone H1.3

1

9

High-throughput

0.437

High

596284

H12
Histone H1.2

1

9

High-throughput

0.437

High

599852

YBOX3
Y-box-binding protein 3

1

3

High-throughput

0.437

High

665478

EF1B
Elongation factor 1-beta

1

1

High-throughput

0.437

High

714937

EF1D
Elongation factor 1-delta

1

1

High-throughput

0.437

High

909649

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

20

High-throughput

0.437

High

935939

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

2

High-throughput

0.437

High

974264

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

2

High-throughput

0.437

High

974441

SMD1
Small nuclear ribonucleoprotein Sm D1

1

3

High-throughput

0.437

High

974807

SMD3
Small nuclear ribonucleoprotein Sm D3

1

3

High-throughput

0.437

High

996797

TBA1B
Tubulin alpha-1B chain

1

9

High-throughput

0.437

High

1004931

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

1016549

SRSF3
Serine/arginine-rich splicing factor 3

1

17

High-throughput

0.437

High

1037304

H11
Histone H1.1

1

9

High-throughput

0.437

High

1051828

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.437

High

1105071

TCOF
Treacle protein

1

12

High-throughput

0.437

High

1120278

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

19

High-throughput

0.437

High

1137123

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

11

High-throughput

0.437

High

1147989

SF3B3
Splicing factor 3B subunit 3

1

3

High-throughput

0.437

High

1198194

PDCD4
Programmed cell death protein 4

1

1

High-throughput

0.437

High

1380579

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.437

High

1380584

SRSF8
Serine/arginine-rich splicing factor 8

1

7

High-throughput

0.437

High

1380595

FBX6
F-box only protein 6

1

9

High-throughput

0.437

High

1380598

ADPRS
ADP-ribosylhydrolase ARH3

1

1

High-throughput

0.437

High

1380599

TBA8
Tubulin alpha-8 chain

1

9

High-throughput

0.437

High

1380603

EI2BD
Translation initiation factor eIF2B subunit delta

1

2

High-throughput

0.437

High

1380604

TBE
Tubulin epsilon chain

1

8

High-throughput

0.437

High

1380612

YBOX2
Y-box-binding protein 2

1

3

High-throughput

0.437

High

1380614

SP16H
FACT complex subunit SPT16

1

4

High-throughput

0.437

High

941953

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.426

High

1348170

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.426

High

1380616

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.426

High

1352328

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.407

High

1380594

EI2BG
Translation initiation factor eIF2B subunit gamma

1

1

High-throughput

0.407

High

1380575

FAKD4
FAST kinase domain-containing protein 4

4

0

High-throughput

0.360

High

1380597

TM160
Transmembrane protein 160

2

0

High-throughput

0.318

High

1380577

BSCL2
Seipin

2

0

High-throughput

0.313

High

1380593

IPPK
Inositol-pentakisphosphate 2-kinase

1

0

High-throughput

0.279

Low

327626

ELP1
Elongator complex protein 1

1

0

High-throughput

0.249

Low

615904

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.249

Low

788731

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.249

Low

1029351

SET
Protein SET

1

0

High-throughput

0.249

Low

1229610

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1380591

ZDHC6
Palmitoyltransferase ZDHHC6

1

0

High-throughput

0.232

Low

1380592

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025