HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0016477 - cell migration GO:0046777 - protein autophosphorylation
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 802 Hs			1 1746
+	Hs
		541686 FGFR1_HUMAN (3-794): 0: 714: 54.76		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		710663 EPHA3_HUMAN (4-778): 0: 617: 18.37		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		931898 EPHA5_HUMAN (4-771): 0: 615: 18.43		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		1147433 EPHA7_HUMAN (4-781): 0: 605: 19.78		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		710892 EPHB2_HUMAN (61-781): 0: 589: 18.54		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		710496 EPHA2_HUMAN (4-789): 0: 587: 19.52		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		1159541 NTRK2_HUMAN (114-757): 1.02e-163: 496: 25.84		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		412620 NTRK1_HUMAN (135-751): 2.17e-160: 487: 26.53		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		464055 RET_HUMAN (221-802): 2.72e-146: 459: 34.72		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		648436 FGFR4_HUMAN (13-802): 0: 755: 100.00		AKT1_HUMAN (1362-1695): 4.45e-91: 307: 15.07
+	Hs
		541360 FGFR1_HUMAN (3-794): 0: 714: 54.76		AKT1_HUMAN (1362-1695): 4.45e-91: 307: 15.07
+	Hs
		541322 FGFR1_HUMAN (3-794): 0: 714: 54.76		KAPCA_HUMAN (1345-1709): 1.11e-90: 301: 18.30
+	Hs
		541542 FGFR1_HUMAN (3-794): 0: 714: 54.76		OBSCN_HUMAN (933-1713): 2.28e-56: 219: 11.37
+	Hs
		728251 EPHA7_HUMAN (4-781): 0: 605: 19.78		AKT1_HUMAN (1362-1695): 4.45e-91: 307: 15.07
+	Hs
		932090 EPHA4_HUMAN (4-776): 0: 597: 19.72		KCC1B_HUMAN (1379-1736): 2.93e-92: 305: 13.97
+	Hs
		710085 EPHA2_HUMAN (4-789): 0: 587: 19.52		AKT1_HUMAN (1362-1695): 4.45e-91: 307: 15.07
+	Hs
		605567 EPHA2_HUMAN (4-789): 0: 587: 19.52		KAPCA_HUMAN (1345-1709): 1.11e-90: 301: 18.30
+	Hs
		640166 EPHA1_HUMAN (3-789): 2.38e-177: 536: 19.55		KCC1A_HUMAN (1453-1709): 3.75e-56: 202: 16.48
+	Hs
		640214 EPHA1_HUMAN (3-789): 2.38e-177: 536: 19.55		KCC1D_HUMAN (1453-1709): 6.21e-53: 193: 15.71