HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.915

The method score is based on:

Property Details
Experiments 11294897, 10918587, 23972473, 24120763, 14732692
Identification Methods enzymatic study, protein kinase assay, nuclear magnetic resonance, surface plasmon resonance
Interaction Type direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains FGFR3_TM~FGFR3_TM, I-set~I-set, I-set~Ig_3, Ig_3~Ig_3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0000165 - MAPK cascade
GO:0001501 - skeletal system development
GO:0001958 - endochondral ossification
GO:0002062 - chondrocyte differentiation
GO:0003416 - endochondral bone growth
and 26 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

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Last updated: 11Aug2025