HitPredict

Interactor 1: SMCA1 (P28370)
Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
Gene: SMARCA1

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	27634302, 24981860, 36517590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1054 Hs			1 746
+	Hs
		229411 SMCA5_HUMAN (32-1051): 0: 1065: 81.86		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1018505 CHD3_HUMAN (31-954): 0: 791: 28.94		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1059639 CHD4_HUMAN (29-960): 0: 789: 28.27		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080420 CHD7_HUMAN (3-1046): 0: 780: 26.74		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080369 CHD8_HUMAN (2-1011): 0: 769: 27.72		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Mm
		1125396 Q5DTP7_MOUSE (29-960): 0: 789: 28.27		Q6AXH7_MOUSE (1-746): 0: 832: 96.41
+	Hs
		1080145 CHD6_HUMAN (1-1039): 0: 750: 26.80		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		229270 SMCA5_HUMAN (32-1051): 0: 1065: 81.86		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		165631 SMCA1_HUMAN (1-1054): 0: 1130: 100.00		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71
+	Hs
		331813 CHD4_HUMAN (29-960): 0: 789: 28.27		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Sc
		744865 ISW1_YEAST (70-1049): 0: 805: 47.63		SET1_YEAST (205-733): 1.13e-84: 292: 16.01
+	Hs
		1059880 CHD4_HUMAN (29-960): 0: 789: 28.27		EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27
+	Hs
		1059797 CHD4_HUMAN (29-960): 0: 789: 28.27		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	Hs
		203687 CHD4_HUMAN (29-960): 0: 789: 28.27		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	Sc
		744881 ISW1_YEAST (70-1049): 0: 805: 47.63		SET2_YEAST (470-733): 1.22e-59: 216: 25.56
+	Hs
		1317720 CHD8_HUMAN (2-1011): 0: 769: 27.72		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42
+	Hs
		975235 CHD3_HUMAN (31-954): 0: 791: 28.94		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		975252 CHD4_HUMAN (29-960): 0: 789: 28.27		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		165677 CHD4_HUMAN (29-960): 0: 789: 28.27		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71
+	Hs
		165721 CHD8_HUMAN (2-1011): 0: 769: 27.72		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71