HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: STYX (Q8WUJ0)
Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)
Gene: STYX

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	28007894
Identification Methods	affinity chromatography technology, protein complementation assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	DSPc~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 223
+	Hs
		658798 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS1_HUMAN (4-199): 1.03e-64: 206: 29.59
+	Hs
		658960 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS5_HUMAN (2-203): 4.01e-62: 200: 29.27
+	Hs
		647475 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS1_HUMAN (4-199): 1.03e-64: 206: 29.59
+	Hs
		659034 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS9_HUMAN (3-191): 6.24e-61: 197: 28.13
+	Hs
		658919 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS4_HUMAN (12-201): 2.57e-60: 195: 28.80
+	Hs
		658962 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS7_HUMAN (16-188): 2.37e-58: 191: 30.46
+	Hs
		659043 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS16_HUMAN (7-186): 2.52e-56: 191: 27.22
+	Hs
		658903 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS2_HUMAN (9-175): 4.33e-59: 190: 36.05
+	Hs
		647563 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS4_HUMAN (12-201): 2.57e-60: 195: 28.80
+	Hs
		658961 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS6_HUMAN (16-188): 4.93e-57: 186: 29.89
+	Mm
		926439 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS6_MOUSE (16-179): 7.66e-57: 186: 30.49
+	Rn
		926496 MK01_RAT (10-360): 4.96e-158: 449: 99.72		DUS6_RAT (16-188): 6.31e-57: 186: 29.89
+	Hs
		658923 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS8_HUMAN (10-174): 2.93e-54: 185: 33.33
+	Mm
		926403 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS2_MOUSE (9-175): 5.66e-57: 184: 33.14
+	Hs
		647553 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS2_HUMAN (9-175): 4.33e-59: 190: 36.05
+	Hs
		658858 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS3_HUMAN (3-182): 2.87e-57: 181: 27.57
+	Mm
		926438 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS3_MOUSE (3-182): 2.76e-56: 178: 26.49
+	Hs
		647564 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS8_HUMAN (10-174): 2.93e-54: 185: 33.33
+	Hs
		659006 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS19_HUMAN (32-187): 5.31e-55: 176: 33.97
+	Hs
		647521 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS3_HUMAN (3-182): 2.87e-57: 181: 27.57