HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	12400011
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016525 - negative regulation of angiogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 583
+	Hs
		666048 EPHA5_HUMAN (11-976): 0: 1127: 51.34		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		666049 EPHA4_HUMAN (1-976): 0: 1121: 50.25		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		208996 EPHA2_HUMAN (1-976): 0: 1141: 100.00		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		665246 EPHA2_HUMAN (1-976): 0: 1141: 100.00		SHB_HUMAN (369-579): 2.01e-41: 158: 20.63
+	Hs
		655219 EPHA2_HUMAN (1-976): 0: 1141: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		1072502 EPHA7_HUMAN (4-974): 0: 1128: 50.30		SHB_HUMAN (369-579): 2.01e-41: 158: 20.63
+	Hs
		209018 EPHA4_HUMAN (1-976): 0: 1121: 50.25		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		557643 EPHA5_HUMAN (11-976): 0: 1127: 51.34		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		655380 EPHA7_HUMAN (4-974): 0: 1128: 50.30		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		655284 EPHA5_HUMAN (11-976): 0: 1127: 51.34		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		655285 EPHA4_HUMAN (1-976): 0: 1121: 50.25		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		665299 EPHA2_HUMAN (1-976): 0: 1141: 100.00		P55G_HUMAN (473-581): 3.75e-31: 128: 29.20
+	Hs
		129208 EPHA2_HUMAN (1-976): 0: 1141: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		872468 EPHA5_HUMAN (11-976): 0: 1127: 51.34		P55G_HUMAN (473-581): 3.75e-31: 128: 29.20
+	Hs
		129297 EPHA7_HUMAN (4-974): 0: 1128: 50.30		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		129252 EPHA5_HUMAN (11-976): 0: 1127: 51.34		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		129253 EPHA4_HUMAN (1-976): 0: 1121: 50.25		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		665200 EPHA2_HUMAN (1-976): 0: 1141: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		924590 EPHA7_HUMAN (4-974): 0: 1128: 50.30		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		872422 EPHA5_HUMAN (11-976): 0: 1127: 51.34		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48