HitPredict

Interactor 1: NLE1 (P25382)
Ribosome assembly protein 4 (Notchless protein homolog 1) (Ribosome biogenesis factor RSA4)
Gene: RSA4

Interactor 2: SPB4 (P25808)
ATP-dependent rRNA helicase SPB4 (EC 3.6.4.13) (Suppressor of PAB1 protein 4)
Gene: SPB4

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	30568249, 37811893, 21825077
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Helicase_C~WD40
Common GO terms	GO:0000027 - ribosomal large subunit assembly GO:0005730 - nucleolus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 515 Sc			1 606
+	Sc
		673587 NLE1_YEAST (1-515): 7.7e-149: 437: 100.00		HAS1_YEAST (6-467): 2.43e-138: 414: 30.98
+	Hs
		1369406 NLE1_HUMAN (212-514): 7.7e-78: 253: 23.16		DDX17_HUMAN (2-463): 6.69e-125: 386: 21.89
+	Sc
		673554 NLE1_YEAST (1-515): 7.7e-149: 437: 100.00		DRS1_YEAST (21-392): 3.92e-47: 178: 31.75
+	Sc
		678362 PWP2_YEAST (4-274): 9.95e-42: 161: 12.54		SPB4_YEAST (1-606): 7.37e-148: 442: 100.00
+	Sc
		444437 PWP2_YEAST (4-274): 9.95e-42: 161: 12.54		DED1_YEAST (3-402): 8.19e-139: 418: 25.55
+	Sc
		678448 PWP2_YEAST (4-274): 9.95e-42: 161: 12.54		HAS1_YEAST (6-467): 2.43e-138: 414: 30.98
+	Hs
		965274 WDR5_HUMAN (1-122): 1.77e-18: 88.6: 9.45		DDX18_HUMAN (6-467): 5.11e-159: 472: 29.61
+	Hs
		965048 WDR5_HUMAN (1-122): 1.77e-18: 88.6: 9.45		DDX46_HUMAN (2-597): 1.5e-133: 417: 21.15
+	Hs
		1369337 FBXW7_HUMAN (18-209): 4.4e-25: 111: 13.00		DDX17_HUMAN (2-463): 6.69e-125: 386: 21.89
+	Hs
		1369427 FBW1A_HUMAN (154-389): 7.92e-18: 88.6: 27.66		DDX17_HUMAN (2-463): 6.69e-125: 386: 21.89
+	Hs
		965133 WDR5_HUMAN (1-122): 1.77e-18: 88.6: 9.45		DDX17_HUMAN (2-463): 6.69e-125: 386: 21.89
+	Hs
		141604 FBXW7_HUMAN (18-209): 4.4e-25: 111: 13.00		DDX3X_HUMAN (4-406): 1.33e-114: 358: 24.64
+	Hs
		608525 WDR5_HUMAN (1-122): 1.77e-18: 88.6: 9.45		DDX5_HUMAN (2-446): 1.35e-122: 377: 21.83
+	Hs
		608795 FBW1A_HUMAN (154-389): 7.92e-18: 88.6: 27.66		DDX5_HUMAN (2-446): 1.35e-122: 377: 21.83
+	Hs
		141400 WDR5_HUMAN (1-122): 1.77e-18: 88.6: 9.45		DDX3X_HUMAN (4-406): 1.33e-114: 358: 24.64
+	Hs
		141711 FBW1A_HUMAN (154-389): 7.92e-18: 88.6: 27.66		DDX3X_HUMAN (4-406): 1.33e-114: 358: 24.64
+	Sc
		632627 PWP2_YEAST (4-274): 9.95e-42: 161: 12.54		DBP4_YEAST (21-467): 7.03e-51: 189: 31.36
+	Hs
		984272 GBB2_HUMAN (293-514): 1.04e-34: 135: 20.61		DDX47_HUMAN (23-382): 7.97e-54: 191: 34.35
+	Hs
		1380240 FBXW7_HUMAN (18-209): 4.4e-25: 111: 13.00		DDX41_HUMAN (18-394): 1.19e-47: 178: 30.95
+	Hs
		965230 WDR5_HUMAN (1-122): 1.77e-18: 88.6: 9.45		DDX47_HUMAN (23-382): 7.97e-54: 191: 34.35