HitPredict

Interactor 1: PSA1 (P25786)
Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6)
Gene: PSMA1

Interactor 2: PSMD1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
Gene: PSMD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 263 Hs			1 953
+	Hs
		165399 PSA7_HUMAN (6-234): 5.38e-96: 283: 33.19		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		700715 PSA5_HUMAN (1-236): 4.19e-93: 275: 28.81		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		954888 PSA6_HUMAN (1-240): 7.5e-93: 275: 25.00		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		681704 PSA4_HUMAN (1-233): 2.18e-91: 272: 28.75		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		684 PSA1_HUMAN (1-263): 2.81e-109: 317: 100.00		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		688 PSA5_HUMAN (1-236): 4.19e-93: 275: 28.81		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		698 PSA6_HUMAN (1-240): 7.5e-93: 275: 25.00		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		687 PSA4_HUMAN (1-233): 2.18e-91: 272: 28.75		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Dm
		556720 PSA1_DROME (1-260): 3.17e-99: 292: 52.42		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Dm
		1376919 PSA5_DROME (1-237): 3.38e-92: 273: 28.86		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Sc
		740170 PSA6_YEAST (1-233): 3.28e-83: 250: 52.77		RPN2_YEAST (2-953): 0: 984: 40.26
+	Hs
		680862 PSA1_HUMAN (1-263): 2.81e-109: 317: 100.00		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		165320 PSA7_HUMAN (6-234): 5.38e-96: 283: 33.19		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		700622 PSA5_HUMAN (1-236): 4.19e-93: 275: 28.81		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		954802 PSA6_HUMAN (1-240): 7.5e-93: 275: 25.00		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		681635 PSA4_HUMAN (1-233): 2.18e-91: 272: 28.75		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Dm
		556801 PSA1_DROME (1-260): 3.17e-99: 292: 52.42		Q9VW54_DROME (12-796): 0: 702: 16.86
+	Dm
		1376944 PSA5_DROME (1-237): 3.38e-92: 273: 28.86		Q9VW54_DROME (12-796): 0: 702: 16.86
+	Sp
		1017853 PSA5_SCHPO (1-239): 2.25e-94: 279: 34.82		RPN1_SCHPO (8-794): 0: 666: 18.03
+	Sp
		153633 PSA6_SCHPO (1-261): 3.38e-93: 277: 53.82		RPN1_SCHPO (8-794): 0: 666: 18.03