HitPredict

Interactor 1: PSA7 (O14818)
Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4)
Gene: PSMA7

Interactor 2: PSMD1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
Gene: PSMD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 953
+	Hs
		700715 PSA5_HUMAN (3-232): 1.1e-94: 279: 35.32		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		954888 PSA6_HUMAN (2-236): 1.76e-93: 276: 32.64		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		680999 PSA1_HUMAN (3-244): 4.9e-93: 275: 32.11		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		688 PSA5_HUMAN (3-232): 1.1e-94: 279: 35.32		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		698 PSA6_HUMAN (2-236): 1.76e-93: 276: 32.64		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		684 PSA1_HUMAN (3-244): 4.9e-93: 275: 32.11		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Dm
		1376919 PSA5_DROME (3-233): 1.71e-95: 281: 34.45		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Dm
		652765 PSA71_DROME (3-229): 3.61e-94: 278: 68.72		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Hs
		685 PSA2_HUMAN (3-232): 1.61e-48: 161: 37.87		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Sp
		268024 PSA4_SCHPO (2-248): 8.92e-93: 275: 53.23		RPN2_SCHPO (1-953): 0: 1042: 43.67
+	Sc
		740171 PSA4_YEAST (2-232): 1.42e-93: 277: 58.55		RPN2_YEAST (2-953): 0: 984: 40.26
+	Hs
		165320 PSA7_HUMAN (1-230): 7.07e-104: 302: 100.00		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		700622 PSA5_HUMAN (3-232): 1.1e-94: 279: 35.32		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		954802 PSA6_HUMAN (2-236): 1.76e-93: 276: 32.64		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		680862 PSA1_HUMAN (3-244): 4.9e-93: 275: 32.11		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Dm
		1376944 PSA5_DROME (3-233): 1.71e-95: 281: 34.45		Q9VW54_DROME (12-796): 0: 702: 16.86
+	Dm
		652807 PSA71_DROME (3-229): 3.61e-94: 278: 68.72		Q9VW54_DROME (12-796): 0: 702: 16.86
+	Sp
		1017853 PSA5_SCHPO (3-235): 3.41e-95: 280: 38.49		RPN1_SCHPO (8-794): 0: 666: 18.03
+	Sp
		1017842 PSA4_SCHPO (2-248): 8.92e-93: 275: 53.23		RPN1_SCHPO (8-794): 0: 666: 18.03
+	Sc
		803568 PSA4_YEAST (2-232): 1.42e-93: 277: 58.55		RPN1_YEAST (8-604): 4.61e-149: 468: 15.96