HitPredict

Interactor 1: PSA6 (P60900)
Proteasome subunit alpha type-6 (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) (Proteasome subunit alpha-1) (alpha-1)
Gene: PSMA6

Interactor 2: PSMD1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
Gene: PSMD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 953
+	Hs
		681219 PSA2_HUMAN (7-243): 8.34e-104: 302: 35.44		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		165399 PSA7_HUMAN (9-240): 1.71e-97: 286: 33.62		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		700715 PSA5_HUMAN (1-242): 5.48e-96: 282: 25.91		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		680999 PSA1_HUMAN (1-245): 2.21e-94: 279: 25.91		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		698 PSA6_HUMAN (1-246): 2.61e-110: 318: 100.00		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		685 PSA2_HUMAN (7-243): 8.34e-104: 302: 35.44		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		688 PSA5_HUMAN (1-242): 5.48e-96: 282: 25.91		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		684 PSA1_HUMAN (1-245): 2.21e-94: 279: 25.91		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		687 PSA4_HUMAN (6-239): 6.32e-93: 275: 32.35		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Dm
		1464107 PSA6_DROME (1-246): 2.56e-101: 296: 66.67		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Dm
		1376919 PSA5_DROME (1-243): 1.39e-95: 281: 26.40		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Hs
		954802 PSA6_HUMAN (1-246): 2.61e-110: 318: 100.00		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		681155 PSA2_HUMAN (7-243): 8.34e-104: 302: 35.44		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		165320 PSA7_HUMAN (9-240): 1.71e-97: 286: 33.62		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		700622 PSA5_HUMAN (1-242): 5.48e-96: 282: 25.91		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		680862 PSA1_HUMAN (1-245): 2.21e-94: 279: 25.91		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		681635 PSA4_HUMAN (6-239): 6.32e-93: 275: 32.35		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Dm
		1487651 PSA6_DROME (1-246): 2.56e-101: 296: 66.67		Q9VW54_DROME (12-796): 0: 702: 16.86
+	Dm
		1376944 PSA5_DROME (1-243): 1.39e-95: 281: 26.40		Q9VW54_DROME (12-796): 0: 702: 16.86
+	Sp
		1017853 PSA5_SCHPO (1-245): 3.65e-95: 280: 30.68		RPN1_SCHPO (8-794): 0: 666: 18.03