Protein: PSA6
Proteasome subunit alpha type-6 (Macropain subunit PRE5) (Multicatalytic endopeptidase complex subunit PRE5) (Proteasome component PRE5) (Proteinase YSCE subunit PRE5)

Gene: PSA6, PRE5
Organism: Saccharomyces cerevisiae S288C
Interactions: 87
UniProt ID: P40302

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0010499 - proteasomal ubiquitin-independent protein catabolic process
GO:0019773 - proteasome core complex, alpha-subunit complex
GO:0034515 - proteasome storage granule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

645175

PSB4
Proteasome subunit beta type-4

14

20

Small-scale

0.981

High

636587

PSA7
Probable proteasome subunit alpha type-7

9

20

Small-scale

0.970

High

661524

PSA2
Proteasome subunit alpha type-2

7

20

High-throughput

0.962

High

721262

PSB5
Proteasome subunit beta type-5

7

20

Small-scale

0.958

High

636668

PSA1
Proteasome subunit alpha type-1

6

20

Small-scale

0.943

High

821967

PSA4
Proteasome subunit alpha type-4

5

19

High-throughput

0.922

High

662044

PSB6
Proteasome subunit beta type-6

5

18

High-throughput

0.912

High

821996

RPN5
26S proteasome regulatory subunit RPN5

4

20

Small-scale

0.892

High

661412

PSA3
Proteasome subunit alpha type-3

4

19

Small-scale

0.884

High

735934

PSA5
Proteasome subunit alpha type-5

4

19

Small-scale

0.881

High

797528

UMP1
Proteasome maturation factor UMP1

4

1

Small-scale

0.881

High

800846

PSB1
Proteasome subunit beta type-1

3

20

Small-scale

0.849

High

721314

PSB7
Proteasome subunit beta type-7

3

19

Small-scale

0.839

High

750683

PRS6A
26S proteasome regulatory subunit 6A

3

20

High-throughput

0.827

High

668394

PSB2
Proteasome subunit beta type-2

2

20

High-throughput

0.776

High

779994

POC2
Proteasome assembly chaperone 2

2

1

High-throughput

0.776

High

821972

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

12

20

Small-scale

0.755

High

750846

PRS6B
26S proteasome regulatory subunit 6B homolog

2

20

High-throughput

0.754

High

750952

PRS7
26S proteasome regulatory subunit 7 homolog

2

20

High-throughput

0.754

High

821966

PSA6
Proteasome subunit alpha type-6

2

18

High-throughput

0.754

High

679049

FUB1
Silencing boundary-establishment protein FUB1

3

1

Small-scale

0.739

High

821971

BLM10
Proteasome activator BLM10

2

7

Small-scale

0.727

High

821992

RPN8
26S proteasome regulatory subunit RPN8

5

20

Small-scale

0.712

High

806730

RPN10
26S proteasome regulatory subunit RPN10

4

11

Small-scale

0.697

High

821995

POC4
Proteasome chaperone 4

1

1

Small-scale

0.691

High

738313

RPN12
26S proteasome regulatory subunit RPN12

3

6

High-throughput

0.662

High

821973

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

3

12

High-throughput

0.662

High

675249

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.618

High

679748

CDC48
Cell division control protein 48

1

10

High-throughput

0.618

High

821968

PRS4
26S proteasome regulatory subunit 4 homolog

1

20

High-throughput

0.618

High

821978

PRS10
26S proteasome subunit RPT4

1

20

High-throughput

0.618

High

821984

PRS8
26S proteasome regulatory subunit 8 homolog

1

20

High-throughput

0.618

High

821997

RPN6
26S proteasome regulatory subunit RPN6

1

20

High-throughput

0.618

High

821988

RPN9
26S proteasome regulatory subunit RPN9

2

11

High-throughput

0.611

High

734680

IMB3
Importin subunit beta-3

2

0

High-throughput

0.595

High

740170

RPN2
26S proteasome regulatory subunit RPN2

2

20

Small-scale

0.595

High

803130

ECM29
Proteasome component ECM29

2

12

High-throughput

0.584

High

803567

RPN1
26S proteasome regulatory subunit RPN1

2

20

Small-scale

0.584

High

780549

SHE2
SWI5-dependent HO expression protein 2

2

0

High-throughput

0.565

High

314877

SEM1
26S proteasome complex subunit SEM1

2

0

High-throughput

0.559

High

821989

POC1
Proteasome chaperone 1

1

1

High-throughput

0.553

High

821991

SUB2
ATP-dependent RNA helicase SUB2

1

4

Small-scale

0.541

High

821987

GCN5
Histone acetyltransferase GCN5

1

7

High-throughput

0.536

High

821976

VPS4
Vacuolar protein sorting-associated protein 4

1

20

Small-scale

0.528

High

645058

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.515

High

660859

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

1

High-throughput

0.515

High

670778

SIS1
Protein SIS1

1

4

High-throughput

0.515

High

821977

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.513

High

821999

SUS1
SAGA complex subunit SUS1

1

0

High-throughput

0.513

High

712992

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.508

High

821982

CTF4
DNA polymerase alpha-binding protein

1

3

High-throughput

0.508

High

761114

NOT4
General negative regulator of transcription subunit 4

1

2

High-throughput

0.501

High

821979

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.489

High

803322

YAP3
AP-1-like transcription factor YAP3

1

0

High-throughput

0.486

High

821975

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.486

High

821983

GCR2
Glycolytic genes transcriptional activator GCR2

1

0

High-throughput

0.486

High

821985

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.486

High

821993

RDR1
Protein RDR1

1

0

High-throughput

0.486

High

150287

RPN13
26S proteasome regulatory subunit RPN13

1

1

High-throughput

0.479

High

646424

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.479

High

707252

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

743991

RAD23
UV excision repair protein RAD23

1

20

High-throughput

0.479

High

779246

CENPA
Histone H3-like centromeric protein CSE4

1

4

High-throughput

0.479

High

817060

RPN3
26S proteasome regulatory subunit RPN3

1

7

High-throughput

0.479

High

821980

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.479

High

821981

H3
Histone H3

1

4

High-throughput

0.479

High

821986

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.479

High

821990

RPN7
26S proteasome regulatory subunit RPN7

1

20

High-throughput

0.479

High

821994

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

821998

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.479

High

654785

URE2
Transcriptional regulator URE2

1

6

High-throughput

0.464

High

584921

TRM1
tRNA

1

0

High-throughput

0.458

High

603061

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

735004

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

762973

SPT7
SAGA complex subunit SPT7

1

2

High-throughput

0.445

High

804199

SSZ1
Ribosome-associated complex subunit SSZ1

1

7

High-throughput

0.445

High

818896

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

579493

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.437

High

795016

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

795380

ATG8
Autophagy-related protein 8

1

6

High-throughput

0.437

High

804801

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

1

High-throughput

0.437

High

821969

MLP2
Protein MLP2

1

2

High-throughput

0.437

High

821974

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.407

High

821970

BNI1
Protein BNI1

1

0

High-throughput

0.261

Low

812354

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

581928

CATA
Peroxisomal catalase A

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025