HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 400
+	Hs
		910005 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Mm
		910339 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Hs
		808460 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		683193 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		125318 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		909790 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Hs
		910022 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SAV1_HUMAN (2-252): 3.57e-48: 169: 15.89
+	Hs
		683527 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Dm
		955002 1433E_DROME (3-245): 4.63e-144: 405: 64.90		YAP1_DROME (17-223): 5.05e-46: 164: 22.80
+	Hs
		909674 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		WWC2_HUMAN (121-264): 2.83e-43: 163: 15.97
+	Hs
		683439 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		WWC2_HUMAN (121-264): 2.83e-43: 163: 15.97
+	Hs
		683644 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		MAGI1_HUMAN (10-212): 9.04e-40: 153: 15.74
+	Mm
		910302 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		NED4L_MOUSE (129-395): 4.63e-24: 106: 11.96
+	Hs
		808077 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Hs
		683192 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Mm
		93264 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		E9PXB7_MOUSE (129-395): 7.76e-23: 102: 12.68
+	Rn
		910358 1433E_RAT (3-243): 4.39e-144: 405: 65.43		NEDD4_RAT (129-328): 3.12e-22: 100: 11.65
+	Mm
		808343 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		NEDD4_MOUSE (129-328): 8.42e-21: 96.6: 10.44
+	Hs
		909930 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20
+	Hs
		683637 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20