Protein: PHC1
Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)

Gene: PHC1
Organism: Homo sapiens
Interactions: 85
UniProt ID: P78364

Gene Ontology (top 5):
GO:0001739 - sex chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1006857

PHC2
Polyhomeotic-like protein 2

8

18

Small-scale

0.971

High

1006867

SCMH1
Polycomb protein SCMH1

4

19

High-throughput

0.903

High

1006884

SCML1
Sex comb on midleg-like protein 1

4

18

High-throughput

0.903

High

1006850

SMBT2
Scm-like with four MBT domains protein 2

4

18

High-throughput

0.902

High

1006862

PHC3
Polyhomeotic-like protein 3

4

18

High-throughput

0.895

High

997630

CSK21
Casein kinase II subunit alpha

2

12

High-throughput

0.811

High

1006874

SDCB2
Syntenin-2

2

7

High-throughput

0.783

High

766082

PCGF2
Polycomb group RING finger protein 2

12

20

Small-scale

0.759

High

765374

BMI1
Polycomb complex protein BMI-1

12

20

Small-scale

0.759

High

129713

CBX4
E3 SUMO-protein ligase CBX4

10

20

Small-scale

0.754

High

1006869

RING2
E3 ubiquitin-protein ligase RING2

7

20

Small-scale

0.752

High

1006879

CBX8
Chromobox protein homolog 8

6

20

High-throughput

0.738

High

1006842

RING1
E3 ubiquitin-protein ligase RING1

6

20

Small-scale

0.736

High

1006845

CBX2
Chromobox protein homolog 2

6

20

Small-scale

0.733

High

338809

CBX6
Chromobox protein homolog 6

5

20

High-throughput

0.718

High

351380

CBX7
Chromobox protein homolog 7

4

20

High-throughput

0.704

High

1006882

SMBT1
Scm-like with four MBT domains protein 1

1

18

High-throughput

0.698

High

1006847

PCGF3
Polycomb group RING finger protein 3

3

20

High-throughput

0.653

High

1006840

PHC1
Polyhomeotic-like protein 1

1

18

High-throughput

0.621

High

625309

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.618

High

1004437

RNF4
E3 ubiquitin-protein ligase RNF4

2

1

High-throughput

0.606

High

980690

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.584

High

1006880

TRPM3
Transient receptor potential cation channel subfamily M member 3

2

4

High-throughput

0.574

High

536952

HSP7C
Heat shock cognate 71 kDa protein

2

2

High-throughput

0.562

High

338730

NPTXR
Neuronal pentraxin receptor

2

8

High-throughput

0.558

High

1006851

TET2
Methylcytosine dioxygenase TET2

1

1

High-throughput

0.552

High

993492

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.541

High

930845

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.536

High

1006846

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1006868

RBM14
RNA-binding protein 14

1

2

High-throughput

0.536

High

1006870

TBA1C
Tubulin alpha-1C chain

1

6

High-throughput

0.536

High

1006885

NFS1
Cysteine desulfurase

1

0

High-throughput

0.513

High

967662

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

5

Small-scale

0.508

High

346951

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.489

High

389276

FINC
Fibronectin

1

1

High-throughput

0.489

High

1006876

PAAT
ATPase PAAT

1

1

High-throughput

0.489

High

297791

PIAS2
E3 SUMO-protein ligase PIAS2

1

1

High-throughput

0.481

High

659207

SP100
Nuclear autoantigen Sp-100

1

14

High-throughput

0.481

High

786536

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

Small-scale

0.481

High

991288

SUMO1
Small ubiquitin-related modifier 1

1

8

High-throughput

0.481

High

1006855

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

5

High-throughput

0.481

High

1006860

ZCHC7
Zinc finger CCHC domain-containing protein 7

1

2

High-throughput

0.481

High

1006875

PPIL3
Peptidyl-prolyl cis-trans isomerase-like 3

1

2

High-throughput

0.481

High

384397

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.480

High

142932

NFIB
Nuclear factor 1 B-type

1

17

High-throughput

0.479

High

259782

BRD4
Bromodomain-containing protein 4

1

16

High-throughput

0.479

High

282699

E2F6
Transcription factor E2F6

1

11

High-throughput

0.479

High

285208

EED
Polycomb protein EED

1

15

High-throughput

0.479

High

413602

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

473908

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

487187

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.479

High

851512

GATA4
Transcription factor GATA-4

1

6

High-throughput

0.479

High

855424

ATRX
Transcriptional regulator ATRX

1

9

Small-scale

0.479

High

992130

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.479

High

998197

H31
Histone H3.1

1

20

High-throughput

0.479

High

1006841

TF65
Transcription factor p65

1

10

High-throughput

0.479

High

1006843

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1006844

MDC1
Mediator of DNA damage checkpoint protein 1

1

8

High-throughput

0.479

High

1006848

BCORL
BCL-6 corepressor-like protein 1

1

14

High-throughput

0.479

High

1006853

BCOR
BCL-6 corepressor

1

14

High-throughput

0.479

High

1006854

PCGF5
Polycomb group RING finger protein 5

1

20

High-throughput

0.479

High

1006856

MGAP
MAX gene-associated protein

1

6

High-throughput

0.479

High

1006858

YAF2
YY1-associated factor 2

1

9

High-throughput

0.479

High

1006861

RYBP
RING1 and YY1-binding protein

1

9

High-throughput

0.479

High

1006863

KDM2B
Lysine-specific demethylase 2B

1

5

High-throughput

0.479

High

1006865

HDAC2
Histone deacetylase 2

1

14

High-throughput

0.479

High

1006866

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

16

High-throughput

0.479

High

1006872

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.479

High

1006873

PCGF6
Polycomb group RING finger protein 6

1

20

High-throughput

0.479

High

1006877

NANOG
Homeobox protein NANOG

1

19

High-throughput

0.479

High

1006881

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1006883

XPO7
Exportin-7

1

4

High-throughput

0.479

High

1006871

MESP1
Mesoderm posterior protein 1

1

0

Small-scale

0.458

High

899831

FXR1
RNA-binding protein FXR1

1

8

High-throughput

0.457

High

72733

B0QXZ6
Chromobox 6

1

20

High-throughput

0.445

High

503573

TFPT
TCF3 fusion partner

1

2

High-throughput

0.445

High

686091

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.445

High

1006849

Q5T8Z6
Polycomb complex protein BMI-1

1

20

High-throughput

0.445

High

1006852

CAVN1
Caveolae-associated protein 1

1

2

High-throughput

0.445

High

105743

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

1006878

FBRS
Probable fibrosin-1

1

3

High-throughput

0.437

High

1006864

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

0

High-throughput

0.426

High

1006859

FAM9A
Protein FAM9A

2

0

High-throughput

0.316

High

369661

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025