Protein: PHC3
Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3)

Gene: PHC3
Organism: Homo sapiens
Interactions: 78
UniProt ID: Q8NDX5

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1006862

PHC1
Polyhomeotic-like protein 1

4

18

High-throughput

0.895

High

1312463

PHC2
Polyhomeotic-like protein 2

3

19

Small-scale

0.827

High

1336925

SCMH1
Polycomb protein SCMH1

2

18

High-throughput

0.789

High

1336939

SCML1
Sex comb on midleg-like protein 1

2

17

High-throughput

0.789

High

765719

BMI1
Polycomb complex protein BMI-1

8

20

Small-scale

0.750

High

766105

PCGF2
Polycomb group RING finger protein 2

8

20

Small-scale

0.749

High

129773

CBX4
E3 SUMO-protein ligase CBX4

6

20

Small-scale

0.729

High

351397

CBX7
Chromobox protein homolog 7

5

20

High-throughput

0.722

High

1336926

RING2
E3 ubiquitin-protein ligase RING2

5

20

High-throughput

0.718

High

338909

CBX6
Chromobox protein homolog 6

4

20

High-throughput

0.699

High

1336935

CBX8
Chromobox protein homolog 8

4

20

High-throughput

0.699

High

1132218

CBX2
Chromobox protein homolog 2

4

20

Small-scale

0.686

High

1055827

RING1
E3 ubiquitin-protein ligase RING1

3

20

High-throughput

0.667

High

401164

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

11

High-throughput

0.618

High

463657

LYN
Tyrosine-protein kinase Lyn

1

15

High-throughput

0.618

High

625502

CSK22
Casein kinase II subunit alpha'

1

20

High-throughput

0.618

High

1336922

DDI1
Protein DDI1 homolog 1

3

5

High-throughput

0.609

High

185863

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.573

High

396539

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1103278

CTBP1
C-terminal-binding protein 1

2

4

High-throughput

0.571

High

353452

AGR2
Anterior gradient protein 2 homolog

2

2

High-throughput

0.553

High

414240

P53
Cellular tumor antigen p53

1

6

High-throughput

0.536

High

634538

LMNB1
Lamin-B1

1

5

High-throughput

0.536

High

658284

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.536

High

872543

SOX2
Transcription factor SOX-2

1

18

High-throughput

0.536

High

1123046

FHL2
Four and a half LIM domains protein 2

1

3

High-throughput

0.536

High

1336928

NPAS1
Neuronal PAS domain-containing protein 1

1

3

High-throughput

0.536

High

1336929

TBA1C
Tubulin alpha-1C chain

1

9

High-throughput

0.536

High

437274

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.515

High

390110

ALBU
Albumin

1

0

High-throughput

0.513

High

1277863

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.513

High

1336931

MCRI2
MAPK regulated corepressor interacting protein 2

1

0

High-throughput

0.513

High

347185

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.489

High

548069

PSPC
Surfactant protein C

1

2

High-throughput

0.489

High

1042033

LMNB2
Lamin-B2

1

5

High-throughput

0.489

High

1336938

FBLN5
Fibulin-5

1

11

High-throughput

0.489

High

191003

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

10

High-throughput

0.479

High

260188

BRD4
Bromodomain-containing protein 4

1

14

High-throughput

0.479

High

282752

E2F6
Transcription factor E2F6

1

14

High-throughput

0.479

High

285372

EED
Polycomb protein EED

1

18

High-throughput

0.479

High

487546

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.479

High

549340

SRF
Serum response factor

1

2

High-throughput

0.479

High

606922

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

695973

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

768673

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

913788

ZN131
Zinc finger protein 131

1

2

High-throughput

0.479

High

980008

H4
Histone H4

1

10

High-throughput

0.479

High

980935

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

992261

SKP1
S-phase kinase-associated protein 1

1

2

High-throughput

0.479

High

998560

H31
Histone H3.1

1

20

High-throughput

0.479

High

1045537

TF65
Transcription factor p65

1

10

High-throughput

0.479

High

1048034

TLE3
Transducin-like enhancer protein 3

1

12

High-throughput

0.479

High

1185924

PCGF3
Polycomb group RING finger protein 3

1

20

High-throughput

0.479

High

1204622

BCORL
BCL-6 corepressor-like protein 1

1

20

High-throughput

0.479

High

1250621

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

1278953

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

15

High-throughput

0.479

High

1286247

PCGF5
Polycomb group RING finger protein 5

1

20

High-throughput

0.479

High

1289463

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1313269

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

1314020

YAF2
YY1-associated factor 2

1

8

High-throughput

0.479

High

1325991

RYBP
RING1 and YY1-binding protein

1

8

High-throughput

0.479

High

1330881

CGAS
Cyclic GMP-AMP synthase

1

3

Small-scale

0.479

High

1336920

NUP43
Nucleoporin Nup43

1

14

High-throughput

0.479

High

1336921

KDM2B
Lysine-specific demethylase 2B

1

9

High-throughput

0.479

High

1336923

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1336924

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

12

High-throughput

0.479

High

1336927

FEV
Protein FEV

1

10

High-throughput

0.479

High

1336930

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.479

High

1336932

PCGF6
Polycomb group RING finger protein 6

1

20

High-throughput

0.479

High

1336937

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1336936

HYPK
Huntingtin-interacting protein K

1

0

High-throughput

0.460

High

1336933

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

503625

TFPT
TCF3 fusion partner

1

2

High-throughput

0.445

High

1239881

CAVN1
Caveolae-associated protein 1

1

3

High-throughput

0.445

High

1336934

FBRS
Probable fibrosin-1

1

3

High-throughput

0.437

High

1161947

H31T
Histone H3.1t

1

20

High-throughput

0.408

High

844836

EAA1
Excitatory amino acid transporter 1

1

3

High-throughput

0.407

High

1064586

HDHD1
Pseudouridine-5'-phosphatase

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025