HitPredict

Interactor 1: CBX6 (O95503)
Chromobox protein homolog 6
Gene: CBX6

Interactor 2: PHC3 (Q8NDX5)
Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3)
Gene: PHC3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	27705803, 22325352, 24981860, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 983
+	Hs
		1336935 CBX8_HUMAN (1-393): 2.32e-76: 243: 30.82		PHC3_HUMAN (1-983): 7.95e-87: 301: 100.00
+	Hs
		338930 CBX6_HUMAN (1-393): 1.4e-116: 347: 100.00		SCMH1_HUMAN (553-982): 7e-39: 156: 17.65
+	Hs
		338809 CBX6_HUMAN (1-393): 1.4e-116: 347: 100.00		PHC1_HUMAN (12-983): 3.36e-35: 147: 22.94
+	Hs
		339011 CBX6_HUMAN (1-393): 1.4e-116: 347: 100.00		SCML2_HUMAN (553-982): 3.27e-33: 139: 17.40
+	Hs
		339007 CBX6_HUMAN (1-393): 1.4e-116: 347: 100.00		SCML1_HUMAN (799-982): 6.56e-33: 132: 22.28
+	Hs
		72733 B0QXZ6_HUMAN (1-393): 3.77e-108: 325: 95.42		PHC1_HUMAN (12-983): 3.36e-35: 147: 22.94
+	Hs
		351397 CBX7_HUMAN (1-207): 2.44e-45: 159: 33.33		PHC3_HUMAN (1-983): 7.95e-87: 301: 100.00
+	Hs
		338894 CBX6_HUMAN (1-393): 1.4e-116: 347: 100.00		PHC2_HUMAN (30-560): 1.94e-17: 89.7: 28.52
+	Hs
		1391692 CBX8_HUMAN (1-393): 2.32e-76: 243: 30.82		SCMH1_HUMAN (553-982): 7e-39: 156: 17.65
+	Hs
		1006879 CBX8_HUMAN (1-393): 2.32e-76: 243: 30.82		PHC1_HUMAN (12-983): 3.36e-35: 147: 22.94
+	Hs
		1438671 CBX8_HUMAN (1-393): 2.32e-76: 243: 30.82		SCML2_HUMAN (553-982): 3.27e-33: 139: 17.40
+	Dr
		1281818 Q804D1_DANRE (1-385): 1.19e-77: 250: 24.21		PHC2_DANRE (172-983): 3.92e-29: 127: 22.98
+	Hs
		1438668 CBX8_HUMAN (1-393): 2.32e-76: 243: 30.82		SCML1_HUMAN (799-982): 6.56e-33: 132: 22.28
+	Dm
		683687 PC_DROME (10-393): 7.52e-58: 196: 21.04		Q9NF31_DROME (370-982): 2.49e-32: 138: 19.15
+	Hs
		1312504 CBX8_HUMAN (1-393): 2.32e-76: 243: 30.82		PHC2_HUMAN (30-560): 1.94e-17: 89.7: 28.52
+	Dm
		683670 PC_DROME (10-393): 7.52e-58: 196: 21.04		PHP_DROME (55-982): 1.9e-26: 119: 15.41
+	Dm
		683694 PC_DROME (10-393): 7.52e-58: 196: 21.04		SCM_DROME (839-980): 2.19e-24: 112: 26.71
+	Hs
		351380 CBX7_HUMAN (1-207): 2.44e-45: 159: 33.33		PHC1_HUMAN (12-983): 3.36e-35: 147: 22.94
+	Dm
		683695 PC_DROME (10-393): 7.52e-58: 196: 21.04		SMBT_DROME (899-981): 3.55e-12: 72.7: 34.94
+	Hs
		351395 CBX7_HUMAN (1-207): 2.44e-45: 159: 33.33		PHC2_HUMAN (30-560): 1.94e-17: 89.7: 28.52