HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: ZFY21 (Q9BQ24)
Zinc finger FYVE domain-containing protein 21 (ZF21)
Gene: ZFYVE21

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28065597
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 234
+	Hs
		338627 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ZFY16_HUMAN (2-202): 3.05e-35: 134: 24.38
+	Hs
		313484 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ZFYV9_HUMAN (3-203): 7.81e-33: 127: 22.54
+	Hs
		159830 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HGS_HUMAN (23-188): 3.11e-32: 125: 22.16
+	Hs
		338594 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGD5_HUMAN (1-169): 2.35e-29: 117: 17.06
+	Hs
		339073 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ANFY1_HUMAN (36-103): 7.64e-25: 104: 36.77
+	Hs
		159886 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		HGS_HUMAN (23-188): 3.11e-32: 125: 22.16
+	Hs
		159848 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		HGS_HUMAN (23-188): 3.11e-32: 125: 22.16
+	Hs
		872668 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		ZFY16_HUMAN (2-202): 3.05e-35: 134: 24.38
+	Hs
		665621 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ZFY16_HUMAN (2-202): 3.05e-35: 134: 24.38
+	Hs
		1072532 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		ZFY16_HUMAN (2-202): 3.05e-35: 134: 24.38
+	Hs
		313518 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		ZFYV9_HUMAN (3-203): 7.81e-33: 127: 22.54
+	Hs
		159938 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		HGS_HUMAN (23-188): 3.11e-32: 125: 22.16
+	Hs
		159900 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		HGS_HUMAN (23-188): 3.11e-32: 125: 22.16
+	Hs
		313540 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		ZFYV9_HUMAN (3-203): 7.81e-33: 127: 22.54
+	Hs
		160216 EPHA6_HUMAN (629-1016): 8.37e-118: 393: 27.80		HGS_HUMAN (23-188): 3.11e-32: 125: 22.16
+	Hs
		160004 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		HGS_HUMAN (23-188): 3.11e-32: 125: 22.16
+	Hs
		159897 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		HGS_HUMAN (23-188): 3.11e-32: 125: 22.16
+	Hs
		159843 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		HGS_HUMAN (23-188): 3.11e-32: 125: 22.16
+	Hs
		159898 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		HGS_HUMAN (23-188): 3.11e-32: 125: 22.16
+	Hs
		665348 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		ANFY1_HUMAN (36-103): 7.64e-25: 104: 36.77