Protein: PHC2
Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)

Gene: PHC2
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q8IXK0

Gene Ontology (top 5):
GO:0000792 - heterochromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1006857

PHC1
Polyhomeotic-like protein 1

8

18

Small-scale

0.971

High

1312455

PHC2
Polyhomeotic-like protein 2

4

19

Small-scale

0.895

High

1312481

SCMH1
Polycomb protein SCMH1

3

19

High-throughput

0.864

High

1312512

SMBT1
Scm-like with four MBT domains protein 1

2

19

High-throughput

0.834

High

1312463

PHC3
Polyhomeotic-like protein 3

3

19

Small-scale

0.827

High

1312482

LMBL3
Lethal(3)malignant brain tumor-like protein 3

2

19

High-throughput

0.826

High

879736

MAPK2
MAP kinase-activated protein kinase 2

2

4

Small-scale

0.800

High

1312514

SCML1
Sex comb on midleg-like protein 1

2

19

High-throughput

0.789

High

765689

BMI1
Polycomb complex protein BMI-1

14

20

Small-scale

0.763

High

766101

PCGF2
Polycomb group RING finger protein 2

11

20

Small-scale

0.759

High

1312516

SCML2
Sex comb on midleg-like protein 2

2

19

Small-scale

0.754

High

1312504

CBX8
Chromobox protein homolog 8

8

20

Small-scale

0.754

High

351395

CBX7
Chromobox protein homolog 7

7

20

Small-scale

0.750

High

1312485

RING2
E3 ubiquitin-protein ligase RING2

8

20

Small-scale

0.750

High

920100

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.740

High

140347

SDCB1
Syntenin-1

1

4

High-throughput

0.740

High

1095407

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

2

High-throughput

0.740

High

129763

CBX4
E3 SUMO-protein ligase CBX4

6

20

Small-scale

0.735

High

1055822

RING1
E3 ubiquitin-protein ligase RING1

6

20

Small-scale

0.733

High

1132211

CBX2
Chromobox protein homolog 2

6

20

Small-scale

0.732

High

338894

CBX6
Chromobox protein homolog 6

5

20

High-throughput

0.722

High

1160821

MAPK3
MAP kinase-activated protein kinase 3

1

4

Small-scale

0.713

High

1307742

SIAH1
E3 ubiquitin-protein ligase SIAH1

4

5

Small-scale

0.707

High

1161142

MK06
Mitogen-activated protein kinase 6

1

5

High-throughput

0.656

High

1014549

SMAD3
Mothers against decapentaplegic homolog 3

2

2

High-throughput

0.654

High

1312473

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

1

High-throughput

0.654

High

612695

RL7
Large ribosomal subunit protein uL30

3

0

High-throughput

0.649

High

681865

RBTN2
Rhombotin-2

2

12

High-throughput

0.640

High

1118911

BYST
Bystin

2

1

High-throughput

0.640

High

1312517

DRG1
Developmentally-regulated GTP-binding protein 1

2

1

High-throughput

0.640

High

682063

RBTN1
Rhombotin-1

2

12

High-throughput

0.633

High

1312472

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

2

High-throughput

0.633

High

1185920

PCGF3
Polycomb group RING finger protein 3

2

20

High-throughput

0.631

High

1286243

PCGF5
Polycomb group RING finger protein 5

2

20

High-throughput

0.631

High

1312484

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

2

5

High-throughput

0.628

High

1158134

MK14
Mitogen-activated protein kinase 14

1

5

Small-scale

0.621

High

909084

NEK4
Serine/threonine-protein kinase Nek4

1

3

High-throughput

0.618

High

401117

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.618

High

625480

CSK22
Casein kinase II subunit alpha'

1

13

Small-scale

0.618

High

997838

CSK21
Casein kinase II subunit alpha

1

11

Small-scale

0.618

High

855676

CRK
Adapter molecule crk

2

12

High-throughput

0.594

High

995123

CSK2B
Casein kinase II subunit beta

2

1

Small-scale

0.586

High

260161

BRD4
Bromodomain-containing protein 4

2

13

High-throughput

0.584

High

980910

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.584

High

1312489

PCGF1
Polycomb group RING finger protein 1

2

20

High-throughput

0.584

High

1006531

SRPK2
SRSF protein kinase 2

1

6

High-throughput

0.575

High

548055

PSPC
Surfactant protein C

2

2

High-throughput

0.574

High

935554

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.573

High

983675

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.573

High

1126993

RBM39
RNA-binding protein 39

1

2

High-throughput

0.573

High

1136814

MO4L2
Mortality factor 4-like protein 2

1

2

High-throughput

0.573

High

1312461

MAGB6
Melanoma-associated antigen B6

1

3

High-throughput

0.573

High

1312471

TRI41
E3 ubiquitin-protein ligase TRIM41

1

4

High-throughput

0.573

High

396470

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1312479

MCRS1
Microspherule protein 1

1

0

High-throughput

0.558

High

787045

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

2

High-throughput

0.553

High

208863

ZBT24
Zinc finger and BTB domain-containing protein 24

1

0

High-throughput

0.549

High

215139

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

0

High-throughput

0.549

High

1185273

F161A
Protein FAM161A

1

0

High-throughput

0.549

High

1312459

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.549

High

1312467

ZN417
Zinc finger protein 417

1

0

High-throughput

0.549

High

1312469

AEN
Apoptosis-enhancing nuclease

1

0

High-throughput

0.549

High

1312475

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.549

High

1312483

ZMAT2
Zinc finger matrin-type protein 2

1

0

High-throughput

0.549

High

1312490

THAP7
THAP domain-containing protein 7

1

0

High-throughput

0.549

High

1312497

SPC1L
Speriolin-like protein

1

0

High-throughput

0.549

High

1312508

AIRIM
AFG2-interacting ribosome maturation factor

1

0

High-throughput

0.549

High

1312518

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.549

High

685030

DNMT1
DNA

1

3

High-throughput

0.541

High

900024

FXR1
RNA-binding protein FXR1

1

10

High-throughput

0.541

High

900407

FXR2
RNA-binding protein FXR2

1

10

High-throughput

0.541

High

1116529

FHL3
Four and a half LIM domains protein 3

1

5

High-throughput

0.541

High

1312466

LMO3
LIM domain only protein 3

1

12

High-throughput

0.541

High

1312477

TRI63
E3 ubiquitin-protein ligase TRIM63

1

4

High-throughput

0.541

High

1312496

TRI55
Tripartite motif-containing protein 55

1

7

High-throughput

0.541

High

1312519

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.541

High

250697

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.536

High

785283

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

872510

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.536

High

1163042

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1218513

ZN691
Zinc finger protein 691

1

1

High-throughput

0.536

High

1312488

TBA1C
Tubulin alpha-1C chain

1

5

High-throughput

0.536

High

1289909

F124A
Protein FAM124A

1

1

High-throughput

0.523

High

1312462

MB213
Protein mab-21-like 3

1

4

High-throughput

0.523

High

1312493

KIFC3
Kinesin-like protein KIFC3

1

1

High-throughput

0.523

High

1312494

AP1M1
AP-1 complex subunit mu-1

1

1

High-throughput

0.523

High

1312499

CARD9
Caspase recruitment domain-containing protein 9

1

1

High-throughput

0.523

High

888179

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.518

High

167316

KLF11
Krueppel-like factor 11

1

14

High-throughput

0.515

High

246744

KDM1A
Lysine-specific histone demethylase 1A

1

20

High-throughput

0.508

High

1217740

GFI1B
Zinc finger protein Gfi-1b

1

1

High-throughput

0.508

High

465001

SP1
Transcription factor Sp1

1

9

Small-scale

0.506

High

1312460

KCD17
BTB/POZ domain-containing protein KCTD17

1

6

High-throughput

0.489

High

1312500

CPVL
Probable serine carboxypeptidase CPVL

1

3

High-throughput

0.489

High

1312510

FBLN5
Fibulin-5

1

2

High-throughput

0.489

High

594043

NCK1
SH2/SH3 adapter protein NCK1

1

11

High-throughput

0.481

High

855900

CRKL
Crk-like protein

1

12

High-throughput

0.481

High

921048

FOSB
Protein FosB

1

7

High-throughput

0.481

High

936561

AF17
Protein AF-17

1

7

High-throughput

0.481

High

987759

GRB2
Growth factor receptor-bound protein 2

1

11

High-throughput

0.481

High

1312470

HDAC7
Histone deacetylase 7

1

10

High-throughput

0.481

High

1312515

PLAL2
Zinc finger protein PLAGL2

1

3

High-throughput

0.481

High

216483

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

High-throughput

0.479

High

285354

EED
Polycomb protein EED

1

14

High-throughput

0.479

High

372520

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.479

High

419072

H2A1B
Histone H2A type 1-B/E

1

9

High-throughput

0.479

High

883604

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

904912

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

979954

H4
Histone H4

1

10

High-throughput

0.479

High

1024688

VIGLN
Vigilin

1

4

High-throughput

0.479

High

1045488

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

1141207

BRD3
Bromodomain-containing protein 3

1

16

High-throughput

0.479

High

1204618

BCORL
BCL-6 corepressor-like protein 1

1

16

High-throughput

0.479

High

1250613

BCOR
BCL-6 corepressor

1

14

High-throughput

0.479

High

1312456

YAF2
YY1-associated factor 2

1

7

High-throughput

0.479

High

1312457

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

8

Small-scale

0.479

High

1312458

RYBP
RING1 and YY1-binding protein

1

7

High-throughput

0.479

High

1312465

KDM2B
Lysine-specific demethylase 2B

1

5

High-throughput

0.479

High

1312474

HDAC2
Histone deacetylase 2

1

10

High-throughput

0.479

High

1312476

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

7

Small-scale

0.479

High

1312487

TBX5
T-box transcription factor TBX5

1

7

High-throughput

0.479

High

1312495

PCGF6
Polycomb group RING finger protein 6

1

20

High-throughput

0.479

High

1312505

ANLN
Anillin

1

2

High-throughput

0.479

High

1312506

MDN1
Midasin

1

7

Small-scale

0.479

High

1312511

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1312478

COQA1
Collagen alpha-1(XXVI) chain

1

4

High-throughput

0.470

High

1312520

R4GMX3
Polycomb complex protein BMI-1

1

20

High-throughput

0.457

High

191702

MAGB2
Melanoma-associated antigen B2

1

3

High-throughput

0.445

High

428849

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.445

High

503622

TFPT
TCF3 fusion partner

1

2

High-throughput

0.445

High

584119

FOSL2
Fos-related antigen 2

1

3

High-throughput

0.445

High

601761

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.445

High

686257

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.445

High

1037255

H11
Histone H1.1

1

2

High-throughput

0.445

High

1099151

SRSF5
Serine/arginine-rich splicing factor 5

1

5

High-throughput

0.445

High

1239867

CAVN1
Caveolae-associated protein 1

1

3

High-throughput

0.445

High

1146027

K1H1
Keratin, type I cuticular Ha1

1

3

High-throughput

0.439

High

1312480

KLD7B
Kelch domain-containing protein 7B

1

4

High-throughput

0.439

High

1312491

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.438

High

942735

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

10

High-throughput

0.437

High

1312501

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1312503

FBRS
Probable fibrosin-1

1

3

High-throughput

0.437

High

1312509

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

1312502

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.426

High

1312513

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.426

High

1161932

H31T
Histone H3.1t

1

20

High-throughput

0.408

High

1290425

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

1

1

High-throughput

0.407

High

1312468

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

11

High-throughput

0.407

High

1312498

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.334

High

943677

RWD2B
RWD domain-containing protein 2B

1

0

High-throughput

0.299

High

1165336

SYT16
Synaptotagmin-16

1

0

High-throughput

0.299

High

1312464

FA13C
Protein FAM13C

1

0

High-throughput

0.299

High

1312507

BSDC1
BSD domain-containing protein 1

1

0

High-throughput

0.282

High

183194

KMO
Kynurenine 3-monooxygenase

1

0

High-throughput

0.279

Low

1312486

SORT
Sortilin

1

0

High-throughput

0.279

Low

1153062

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.265

Low

136932

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.249

Low

1312492

PBDC1
Protein PBDC1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025