Protein: SCML2
Sex comb on midleg-like protein 2

Gene: SCML2
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q9UQR0

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0009653 - anatomical structure morphogenesis
GO:0031519 - PcG protein complex
GO:0042393 - histone binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1218287

SMBT2
Scm-like with four MBT domains protein 2

2

19

High-throughput

0.783

High

1312516

PHC2
Polyhomeotic-like protein 2

2

19

Small-scale

0.754

High

1371788

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

7

4

Small-scale

0.753

High

1404843

RING2
E3 ubiquitin-protein ligase RING2

5

20

Small-scale

0.709

High

1348580

LNX1
E3 ubiquitin-protein ligase LNX

2

2

High-throughput

0.700

High

668079

CDK2
Cyclin-dependent kinase 2

1

1

Small-scale

0.691

High

1391697

SCMH1
Polycomb protein SCMH1

1

19

High-throughput

0.691

High

163196

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.687

High

443565

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.646

High

808203

CDN1A
Cyclin-dependent kinase inhibitor 1

2

1

Small-scale

0.608

High

1005253

RNF4
E3 ubiquitin-protein ligase RNF4

2

2

High-throughput

0.606

High

980555

H4
Histone H4

2

11

High-throughput

0.584

High

397245

ESR1
Estrogen receptor

2

12

High-throughput

0.571

High

222227

NCK2
Cytoplasmic protein NCK2

2

6

High-throughput

0.553

High

74647

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

3

High-throughput

0.536

High

407733

S100B
Protein S100-B

1

4

High-throughput

0.536

High

1163298

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1438671

CBX8
Chromobox protein homolog 8

1

20

High-throughput

0.536

High

231654

PRKY
Putative serine/threonine-protein kinase PRKY

1

1

High-throughput

0.514

High

49178

POTB3
POTE ankyrin domain family member B3

2

1

High-throughput

0.504

High

355356

CCNE2
G1/S-specific cyclin-E2

1

1

Small-scale

0.500

High

857364

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

1

Small-scale

0.500

High

649755

SPR1B
Cornifin-B

1

1

High-throughput

0.489

High

1247468

POTEG
POTE ankyrin domain family member G

1

1

High-throughput

0.489

High

1402743

TCPQM
T-complex protein 1 subunit theta-like 2

1

6

High-throughput

0.489

High

129564

MEN1
Menin

1

1

High-throughput

0.479

High

129830

CBX4
E3 SUMO-protein ligase CBX4

1

20

Small-scale

0.479

High

355621

NSD2
Histone-lysine N-methyltransferase NSD2

1

10

Small-scale

0.479

High

386370

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.479

High

419277

H2A1B
Histone H2A type 1-B/E

1

5

High-throughput

0.479

High

520462

ANDR
Androgen receptor

1

12

High-throughput

0.479

High

590053

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

696886

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

755034

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

766022

BMI1
Polycomb complex protein BMI-1

1

20

Small-scale

0.479

High

831665

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

862563

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

903522

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

5

Small-scale

0.479

High

981182

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

998957

H31
Histone H3.1

1

20

High-throughput

0.479

High

1008940

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.479

High

1017309

H33
Histone H3.3

1

20

High-throughput

0.479

High

1033820

PO5F1
POU domain, class 5, transcription factor 1

1

6

High-throughput

0.479

High

1097636

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1132248

CBX2
Chromobox protein homolog 2

1

20

Small-scale

0.479

High

1141370

BRD3
Bromodomain-containing protein 3

1

11

High-throughput

0.479

High

1157997

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.479

High

1276981

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1289730

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1313539

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.479

High

1364308

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

1405578

TBX5
T-box transcription factor TBX5

1

5

High-throughput

0.479

High

1429019

WWTR1
WW domain-containing transcription regulator protein 1

1

2

High-throughput

0.479

High

1462772

DCAF1
DDB1- and CUL4-associated factor 1

1

2

Small-scale

0.479

High

46624

A0A286YEY3
SLIT-ROBO Rho GTPase activating protein 2B

1

2

High-throughput

0.470

High

558505

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

697296

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

986822

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1086727

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.458

High

339011

CBX6
Chromobox protein homolog 6

1

20

High-throughput

0.445

High

516077

SRG2B
SLIT-ROBO Rho GTPase-activating protein 2B

1

2

High-throughput

0.439

High

346516

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.437

High

769535

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

964777

DCAF7
DDB1- and CUL4-associated factor 7

1

4

Small-scale

0.437

High

1245153

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.437

High

1352402

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.437

High

1434255

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1454775

HECW2
E3 ubiquitin-protein ligase HECW2

1

4

High-throughput

0.437

High

1437262

CB39L
Calcium-binding protein 39-like

2

0

High-throughput

0.316

High

370375

CYTA
Cystatin-A

1

0

High-throughput

0.279

Low

612017

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.279

Low

652439

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.279

Low

762260

TRY3
Trypsin-3

1

0

High-throughput

0.279

Low

400042

CATA
Catalase

1

0

High-throughput

0.249

Low

452441

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.249

Low

1398408

CEP63
Centrosomal protein of 63 kDa

1

0

High-throughput

0.249

Low

1432727

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025