HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: FOXO1 (Q12778)
Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)
Gene: FOXO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	28205554, 36931259
Identification Methods	fluorescent resonance energy transfer, cross-linking study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 655
+	Hs
		909490 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FOXO1_HUMAN (1-655): 2.55e-104: 332: 100.00
+	Hs
		206808 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		FOXO3_HUMAN (4-655): 4.4e-83: 277: 39.00
+	Hs
		926976 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		FOXO1_HUMAN (1-655): 2.55e-104: 332: 100.00
+	Hs
		206820 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FOXO3_HUMAN (4-655): 4.4e-83: 277: 39.00
+	Hs
		206822 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		FOXO3_HUMAN (4-655): 4.4e-83: 277: 39.00
+	Hs
		646840 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		FOXO1_HUMAN (1-655): 2.55e-104: 332: 100.00
+	Hs
		683962 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		FOXO4_HUMAN (3-634): 7.43e-45: 169: 34.65
+	Hs
		206799 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		FOXO3_HUMAN (4-655): 4.4e-83: 277: 39.00
+	Hs
		909442 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FOXO4_HUMAN (3-634): 7.43e-45: 169: 34.65
+	Hs
		909439 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FOXK1_HUMAN (15-550): 3.5e-43: 168: 15.78
+	Hs
		909499 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FOXC1_HUMAN (120-282): 1.05e-43: 167: 31.33
+	Hs
		206807 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		FOXO3_HUMAN (4-655): 4.4e-83: 277: 39.00
+	Dm
		955013 1433E_DROME (2-247): 2.8e-144: 405: 58.07		FOXO_DROME (88-470): 3.72e-39: 154: 34.27
+	Hs
		926923 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		FOXO4_HUMAN (3-634): 7.43e-45: 169: 34.65
+	Hs
		926921 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		FOXK1_HUMAN (15-550): 3.5e-43: 168: 15.78
+	Hs
		46292 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		A0A1X9RU27_HUMAN (80-655): 3.14e-62: 218: 30.99
+	Hs
		46293 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		A0A1X9RU27_HUMAN (80-655): 3.14e-62: 218: 30.99
+	Hs
		646796 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		FOXK1_HUMAN (15-550): 3.5e-43: 168: 15.78
+	Hs
		68643 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		FOXO6_HUMAN (535-655): 1.92e-11: 68.7: 27.64
+	Hs
		68644 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		FOXO6_HUMAN (535-655): 1.92e-11: 68.7: 27.64