HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: AAPK1 (Q13131)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: PRKAA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 559
+	Hs
		909507 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AAPK1_HUMAN (1-559): 0: 595: 100.00
+	Rn
		871214 1433E_RAT (2-246): 4.41e-146: 410: 60.41		AAPK1_RAT (1-559): 0: 593: 99.11
+	Hs
		683920 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		AAPK2_HUMAN (13-559): 0: 535: 75.41
+	Hs
		871354 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AAPK2_HUMAN (13-559): 0: 535: 75.41
+	Hs
		684157 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK2_HUMAN (10-545): 5.04e-150: 451: 29.64
+	Hs
		647836 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK3_HUMAN (3-543): 7.31e-144: 434: 28.21
+	Hs
		683925 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK1_HUMAN (4-401): 2.75e-142: 431: 38.21
+	Hs
		909730 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK2_HUMAN (10-545): 5.04e-150: 451: 29.64
+	Mm
		910234 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK2_MOUSE (3-545): 1.66e-148: 447: 29.08
+	At
		1280891 14337_ARATH (2-247): 4.35e-147: 413: 58.07		CIPKC_ARATH (8-530): 5.91e-146: 431: 25.48
+	Hs
		647862 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK3_HUMAN (3-543): 7.31e-144: 434: 28.21
+	Mm
		910231 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK3_MOUSE (11-543): 4.46e-143: 432: 28.31
+	Hs
		883214 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SIK1_HUMAN (4-401): 2.75e-142: 431: 38.21
+	Hs
		909916 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK4_HUMAN (18-543): 9.01e-140: 424: 28.76
+	Mm
		910308 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK4_MOUSE (11-404): 2.19e-133: 407: 35.56
+	Hs
		684316 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK2_HUMAN (10-340): 1.75e-85: 286: 42.69
+	Hs
		684192 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		BRSK2_HUMAN (24-376): 3.25e-82: 273: 42.12
+	Hs
		909786 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		BRSK2_HUMAN (24-376): 3.25e-82: 273: 42.12
+	Mm
		910272 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		BRSK2_MOUSE (24-376): 4.35e-82: 273: 42.12
+	Mm
		910248 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		BRSK1_MOUSE (24-279): 1.44e-80: 270: 50.78