Protein: ARK2N
Protein ARK2N (ARKadia-like protein 1) (Arkadia (RNF111) N-terminal like PKA signaling regulator protein 2N)

Gene: ARK2N
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q96B23

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0061630 - ubiquitin protein ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

625545

CSK22
Casein kinase II subunit alpha'

8

2

High-throughput

0.752

High

991393

SUMO1
Small ubiquitin-related modifier 1

5

2

Small-scale

0.720

High

997922

CSK21
Casein kinase II subunit alpha

4

2

High-throughput

0.699

High

230386

CREB3
Cyclic AMP-responsive element-binding protein 3

4

1

High-throughput

0.691

High

1331461

ZFP41
Zinc finger protein 41 homolog

3

0

High-throughput

0.638

High

326209

ALX3
Homeobox protein aristaless-like 3

2

1

High-throughput

0.628

High

583592

ATF2
Cyclic AMP-dependent transcription factor ATF-2

2

2

High-throughput

0.628

High

603675

JUNB
Transcription factor JunB

2

3

High-throughput

0.628

High

1276057

ZN550
Zinc finger protein 550

2

1

High-throughput

0.628

High

1383987

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

2

3

High-throughput

0.628

High

995187

CSK2B
Casein kinase II subunit beta

3

0

High-throughput

0.622

High

993697

UBC9
SUMO-conjugating enzyme UBC9

2

1

High-throughput

0.613

High

1383995

CD11A
Cyclin-dependent kinase 11A

2

1

High-throughput

0.611

High

171912

ZN263
Zinc finger protein 263

2

0

High-throughput

0.602

High

714938

EF1D
Elongation factor 1-delta

2

0

High-throughput

0.602

High

732663

ARRB2
Beta-arrestin-2

2

0

High-throughput

0.602

High

1132184

HLX
H2.0-like homeobox protein

2

0

High-throughput

0.602

High

1383976

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

2

0

High-throughput

0.602

High

1383986

SP110
Sp110 nuclear body protein

2

0

High-throughput

0.585

High

1004944

RNF4
E3 ubiquitin-protein ligase RNF4

2

0

High-throughput

0.580

High

1383973

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

935435

FGF8
Fibroblast growth factor 8

2

2

High-throughput

0.574

High

1383981

ZN692
Zinc finger protein 692

2

3

High-throughput

0.574

High

1006609

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.550

High

1383978

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.550

High

961203

FGF12
Fibroblast growth factor 12

1

2

High-throughput

0.536

High

1275355

H2BWT
Histone H2B type W-T

1

2

High-throughput

0.536

High

1370562

FGF11
Fibroblast growth factor 11

1

2

High-throughput

0.536

High

540927

ERG
Transcriptional regulator ERG

1

0

High-throughput

0.518

High

1121643

MORC3
MORC family CW-type zinc finger protein 3

1

0

High-throughput

0.518

High

107814

SUMO5
Small ubiquitin-related modifier 5

1

2

High-throughput

0.515

High

250310

VINEX
Vinexin

1

0

High-throughput

0.513

High

725102

HXC8
Homeobox protein Hox-C8

1

0

High-throughput

0.513

High

788736

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

987442

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.513

High

1022686

ZXDB
Zinc finger X-linked protein ZXDB

1

0

High-throughput

0.513

High

1111427

DGKZ
Diacylglycerol kinase zeta

1

0

High-throughput

0.513

High

1128661

ZN460
Zinc finger protein 460

1

0

High-throughput

0.513

High

1161797

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.513

High

1323265

SIX5
Homeobox protein SIX5

1

0

High-throughput

0.513

High

1353778

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.513

High

1383972

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.513

High

1383988

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1383994

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

964412

SUMO2
Small ubiquitin-related modifier 2

1

2

Small-scale

0.481

High

508400

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

173189

XPO1
Exportin-1

1

2

High-throughput

0.479

High

256947

H2B1K
Histone H2B type 1-K

1

1

High-throughput

0.479

High

315857

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

316626

ST17B
Serine/threonine-protein kinase 17B

1

1

High-throughput

0.479

High

636127

CD11B
Cyclin-dependent kinase 11B

1

1

High-throughput

0.479

High

764954

CTNB1
Catenin beta-1

1

1

Small-scale

0.479

High

887093

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.479

High

926393

BLM
RecQ-like DNA helicase BLM

1

1

Small-scale

0.479

High

946026

VSX2
Visual system homeobox 2

1

1

High-throughput

0.479

High

980996

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1337826

CSK23
Casein kinase II subunit alpha 3

1

2

High-throughput

0.479

High

1383990

ST17A
Serine/threonine-protein kinase 17A

1

1

High-throughput

0.479

High

1383993

XPO7
Exportin-7

1

2

High-throughput

0.479

High

1270713

Q7KZS0
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.470

High

187152

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.458

High

253672

IMA7
Importin subunit alpha-7

1

0

High-throughput

0.458

High

325038

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

414371

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

714335

PML
Protein PML

1

0

Small-scale

0.458

High

1088953

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1097471

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1252764

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

Small-scale

0.458

High

1383971

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

High-throughput

0.458

High

1383979

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

Small-scale

0.458

High

1383980

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.458

High

1383983

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1383985

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1383992

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

430213

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

725155

HXC9
Homeobox protein Hox-C9

1

1

High-throughput

0.445

High

1327324

ZN276
Zinc finger protein 276

1

1

High-throughput

0.445

High

1383982

ZSA5A
Zinc finger and SCAN domain-containing protein 5A

1

1

High-throughput

0.445

High

279447

TULP3
Tubby-related protein 3

1

0

High-throughput

0.426

High

976917

ERR3
Estrogen-related receptor gamma

1

0

High-throughput

0.426

High

1054132

BTK
Tyrosine-protein kinase BTK

1

0

High-throughput

0.426

High

1239904

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

1271966

ZN765
Zinc finger protein 765

1

0

High-throughput

0.426

High

1383991

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.426

High

846131

CATK
Cathepsin K

3

0

High-throughput

0.347

High

139579

PESC
Pescadillo homolog

3

0

High-throughput

0.345

High

871992

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

0

High-throughput

0.345

High

1204714

TAF7L
Transcription initiation factor TFIID subunit 7-like

2

0

High-throughput

0.328

High

1241020

L2GL2
LLGL scribble cell polarity complex component 2

2

0

High-throughput

0.328

High

1290926

TAXB1
Tax1-binding protein 1

2

0

High-throughput

0.316

High

1383970

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

1383977

JKIP1
Janus kinase and microtubule-interacting protein 1

2

0

High-throughput

0.316

High

1331832

SYT2
Synaptotagmin-2

2

0

High-throughput

0.313

High

1334350

IN80E
INO80 complex subunit E

2

0

High-throughput

0.313

High

164413

NRP1
Neuropilin-1

2

0

High-throughput

0.298

High

1209490

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.279

Low

49572

FEZF1
Fez family zinc finger protein 1

1

0

High-throughput

0.279

Low

871175

TFPI2
Tissue factor pathway inhibitor 2

1

0

High-throughput

0.279

Low

908154

KS6A3
Ribosomal protein S6 kinase alpha-3

1

0

High-throughput

0.279

Low

1314959

ELOA2
Elongin-A2

1

0

High-throughput

0.279

Low

1325069

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

0

High-throughput

0.279

Low

1339315

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.279

Low

1383975

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

1383989

PKHJ1
Pleckstrin homology domain-containing family J member 1

1

0

High-throughput

0.279

Low

1383997

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

191041

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.249

Low

708862

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

0

High-throughput

0.249

Low

844267

MTHR
Methylenetetrahydrofolate reductase

1

0

High-throughput

0.249

Low

984892

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.249

Low

1311826

DHX40
Probable ATP-dependent RNA helicase DHX40

1

0

High-throughput

0.249

Low

1338885

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.249

Low

1383984

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

0

High-throughput

0.249

Low

516115

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low

517323

GOG8G
Golgin subfamily A member 8G

1

0

High-throughput

0.232

Low

1335367

CAMKV
CaM kinase-like vesicle-associated protein

1

0

High-throughput

0.232

Low

1383974

JPH4
Junctophilin-4

1

0

High-throughput

0.232

Low

1383996

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025