HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: BRSK2 (Q8IWQ3)
Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A)
Gene: BRSK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 736
+	Mm
		910272 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		BRSK2_MOUSE (1-736): 0: 638: 97.69
+	Hs
		647836 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK3_HUMAN (7-678): 1.4e-163: 492: 25.76
+	Hs
		684157 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK2_HUMAN (4-678): 5.19e-158: 478: 25.58
+	Mm
		910248 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		BRSK1_MOUSE (16-711): 7.23e-166: 498: 68.90
+	Mm
		910231 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK3_MOUSE (7-678): 1.22e-164: 494: 25.74
+	Hs
		647862 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK3_HUMAN (7-678): 1.4e-163: 492: 25.76
+	Hs
		684364 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK1_HUMAN (8-678): 1.08e-148: 455: 24.37
+	Mm
		910234 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK2_MOUSE (1-678): 1.76e-157: 476: 25.10
+	Hs
		684009 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		AAPK1_HUMAN (2-539): 1.18e-144: 436: 28.73
+	Hs
		684349 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SNRK_HUMAN (14-706): 9.69e-142: 436: 21.21
+	Hs
		683925 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK1_HUMAN (3-508): 8.58e-141: 434: 35.04
+	Hs
		683920 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		AAPK2_HUMAN (5-535): 2.22e-142: 430: 27.89
+	Mm
		910318 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK1_MOUSE (8-678): 2.51e-146: 448: 23.94
+	Mm
		910308 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK4_MOUSE (7-686): 2.65e-142: 436: 25.73
+	Rn
		871214 1433E_RAT (2-246): 4.41e-146: 410: 60.41		AAPK1_RAT (2-539): 2.23e-144: 435: 28.18
+	Hs
		883214 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SIK1_HUMAN (3-508): 8.58e-141: 434: 35.04
+	Hs
		871354 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AAPK2_HUMAN (5-535): 2.22e-142: 430: 27.89
+	At
		1280891 14337_ARATH (2-247): 4.35e-147: 413: 58.07		CIPKC_ARATH (2-328): 9.55e-140: 421: 34.74
+	Hs
		684412 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK3_HUMAN (16-353): 1.45e-78: 276: 43.49
+	Hs
		684316 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK2_HUMAN (9-364): 2.52e-78: 271: 42.78