HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	30240640, 36931259, unassigned3799
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1242
+	Hs
		772478 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		IRS1_HUMAN (1-1242): 1.5e-150: 487: 100.00
+	Mm
		772538 1433E_MOUSE (2-243): 1.32e-144: 406: 63.53		IRS1_MOUSE (1-1242): 2.17e-131: 435: 85.86
+	Dm
		1019970 1433E_DROME (2-242): 6.8e-143: 401: 65.02		IRS1_DROME (6-716): 2.59e-83: 295: 19.90
+	Hs
		160466 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		IRS4_HUMAN (11-1066): 1.4e-79: 288: 22.13
+	Dm
		709604 1433Z_DROME (1-245): 3.69e-141: 397: 77.14		IRS1_DROME (6-716): 2.59e-83: 295: 19.90
+	Hs
		972174 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		IRS2_HUMAN (13-1194): 3.32e-78: 285: 29.03
+	Hs
		160418 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		IRS4_HUMAN (11-1066): 1.4e-79: 288: 22.13
+	Hs
		160471 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		IRS4_HUMAN (11-1066): 1.4e-79: 288: 22.13
+	Hs
		691578 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		IRS2_HUMAN (13-1194): 3.32e-78: 285: 29.03
+	Hs
		690935 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		ZO1_HUMAN (284-1059): 9.45e-34: 143: 9.58
+	Hs
		971417 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		ANK2_HUMAN (257-1242): 4.96e-31: 135: 11.92
+	Hs
		67646 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		RHG32_HUMAN (302-1240): 8.59e-30: 131: 12.77
+	Hs
		690915 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		ANK2_HUMAN (257-1242): 4.96e-31: 135: 11.92
+	Hs
		67618 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		RHG32_HUMAN (302-1240): 8.59e-30: 131: 12.77
+	Hs
		67651 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		RHG32_HUMAN (302-1240): 8.59e-30: 131: 12.77
+	Hs
		319058 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		K0754_HUMAN (228-597): 6.15e-18: 92.7: 12.37
+	Hs
		971678 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		OTOG_HUMAN (430-949): 2.8e-13: 77.1: 10.85
+	Hs
		691153 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		OTOG_HUMAN (430-949): 2.8e-13: 77.1: 10.85
+	Hs
		274129 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		ANR17_HUMAN (679-1220): 3.63e-09: 63.7: 12.68
+	Hs
		274099 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		ANR17_HUMAN (679-1220): 3.63e-09: 63.7: 12.68