HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: M3K2 (Q9Y2U5)
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
Gene: MAP3K2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	33961781, 36931259, 26496610, 32707033, 36736316, 28514442, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 619
+	Hs
		972164 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		M3K2_HUMAN (1-619): 0: 586: 100.00
+	Hs
		971928 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		M3K3_HUMAN (1-615): 6.44e-178: 519: 64.59
+	Hs
		691370 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		M3K3_HUMAN (1-615): 6.44e-178: 519: 64.59
+	Hs
		971778 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		DCLK2_HUMAN (22-618): 2.43e-140: 428: 19.07
+	Mm
		972250 1433E_MOUSE (2-243): 1.32e-144: 406: 63.53		DCLK2_MOUSE (22-618): 1.07e-138: 423: 18.91
+	Hs
		691242 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		DCLK2_HUMAN (22-618): 2.43e-140: 428: 19.07
+	Hs
		176814 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		DCLK1_HUMAN (22-618): 9.51e-135: 412: 16.72
+	Mm
		972321 1433E_MOUSE (2-243): 1.32e-144: 406: 63.53		DCLK1_MOUSE (22-618): 5.38e-132: 406: 17.05
+	Hs
		176798 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		DCLK1_HUMAN (22-618): 9.51e-135: 412: 16.72
+	Hs
		176815 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		DCLK1_HUMAN (22-618): 9.51e-135: 412: 16.72
+	Hs
		972086 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		PAK5_HUMAN (4-617): 1.77e-129: 398: 20.21
+	Hs
		691500 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		PAK5_HUMAN (4-617): 1.77e-129: 398: 20.21
+	At
		1030913 14332_ARATH (3-243): 8.69e-144: 404: 61.22		CIPKC_ARATH (336-618): 2.04e-128: 388: 26.67
+	At
		840534 14333_ARATH (3-243): 8.04e-143: 401: 61.63		CIPKC_ARATH (336-618): 2.04e-128: 388: 26.67
+	At
		1379653 14337_ARATH (2-243): 2.79e-142: 400: 60.32		CIPKC_ARATH (336-618): 2.04e-128: 388: 26.67
+	Dm
		94942 1433E_DROME (2-242): 6.8e-143: 401: 65.02		E1JGN0_DROME (203-617): 1.35e-110: 359: 22.70
+	At
		840482 14333_ARATH (3-243): 8.04e-143: 401: 61.63		M3K2_ARATH (294-617): 2.17e-113: 354: 42.77
+	Xl
		237423 O57468_XENLA (2-243): 4.55e-144: 404: 64.75		Q804T2_XENLA (293-618): 5.46e-110: 348: 27.96
+	Hs
		971475 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		M3K1_HUMAN (351-613): 5.84e-51: 192: 42.13
+	Hs
		690968 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		M3K1_HUMAN (351-613): 5.84e-51: 192: 42.13