HitPredict

Interactor 1: CALR (P27797)
Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)
Gene: CALR

Interactor 2: TMX1 (Q9H3N1)
Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein)
Gene: TMX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 417 Hs			1 280
+	Hs
		1396540 CALR3_HUMAN (1-362): 1.51e-165: 471: 51.38		TMX1_HUMAN (1-280): 3.89e-79: 242: 100.00
+	Hs
		697992 CALR_HUMAN (18-417): 0: 519: 100.00		TMX3_HUMAN (6-270): 2.39e-44: 157: 15.94
+	Dm
		712382 CALR_DROME (4-406): 7.46e-167: 475: 66.58		PDIA6_DROME (6-275): 2.48e-60: 199: 16.50
+	Hs
		698008 CALR_HUMAN (18-417): 0: 519: 100.00		ERP44_HUMAN (1-161): 1.6e-38: 141: 23.12
+	Hs
		697886 CALR_HUMAN (18-417): 0: 519: 100.00		PDIA6_HUMAN (25-146): 2.92e-34: 130: 31.01
+	Dm
		712341 CALR_DROME (4-406): 7.46e-167: 475: 66.58		Q3YMU0_DROME (15-172): 5.21e-38: 141: 24.24
+	Hs
		1396535 CALR3_HUMAN (1-362): 1.51e-165: 471: 51.38		ERP44_HUMAN (1-161): 1.6e-38: 141: 23.12
+	Hs
		1127935 CALR3_HUMAN (1-362): 1.51e-165: 471: 51.38		PDIA5_HUMAN (4-243): 8.73e-36: 135: 14.06
+	Hs
		1142366 CALR3_HUMAN (1-362): 1.51e-165: 471: 51.38		PDIA6_HUMAN (25-146): 2.92e-34: 130: 31.01
+	Hs
		566560 CALR_HUMAN (18-417): 0: 519: 100.00		PDIA4_HUMAN (119-266): 1.21e-16: 81.3: 9.68
+	Hs
		1334116 CALR3_HUMAN (1-362): 1.51e-165: 471: 51.38		TXND5_HUMAN (24-135): 7.67e-33: 126: 25.86
+	Hs
		697777 CALR_HUMAN (18-417): 0: 519: 100.00		PDIA3_HUMAN (147-269): 6.26e-15: 76.3: 11.29
+	Hs
		697944 CALR_HUMAN (18-417): 0: 519: 100.00		DJC10_HUMAN (75-264): 9.7e-14: 72.9: 10.53
+	At
		146277 CALR1_ARATH (7-359): 4.53e-150: 433: 54.34		PDI21_ARATH (28-175): 9.94e-35: 130: 27.39
+	Hs
		566803 CALR3_HUMAN (1-362): 1.51e-165: 471: 51.38		PDIA4_HUMAN (119-266): 1.21e-16: 81.3: 9.68
+	Hs
		717574 CALR3_HUMAN (1-362): 1.51e-165: 471: 51.38		PDIA3_HUMAN (147-269): 6.26e-15: 76.3: 11.29
+	Hs
		1312041 CALR3_HUMAN (1-362): 1.51e-165: 471: 51.38		DJC10_HUMAN (75-264): 9.7e-14: 72.9: 10.53
+	Dm
		712329 CALR_DROME (4-406): 7.46e-167: 475: 66.58		PDI_DROME (60-261): 4.32e-11: 64.8: 13.02
+	Hs
		452369 CALR3_HUMAN (1-362): 1.51e-165: 471: 51.38		PDIA1_HUMAN (66-256): 3.31e-10: 62.1: 10.68
+	Hs
		452173 CALX_HUMAN (20-416): 1.51e-145: 428: 34.39		PDIA1_HUMAN (66-256): 3.31e-10: 62.1: 10.68