HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: RND2 (P52198)
Rho-related GTP-binding protein RhoN (Rho family GTPase 2) (Rho-related GTP-binding protein Rho7) (Rnd2)
Gene: RND2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 227
+	Hs
		699677 P85A_HUMAN (1-724): 0: 590: 100.00		RND3_HUMAN (4-227): 5.97e-99: 289: 64.00
+	Hs
		699683 P85A_HUMAN (1-724): 0: 590: 100.00		RHOB_HUMAN (5-185): 8.64e-92: 269: 45.86
+	Hs
		699676 P85A_HUMAN (1-724): 0: 590: 100.00		RHOA_HUMAN (9-193): 3.39e-84: 250: 47.03
+	Hs
		699696 P85A_HUMAN (1-724): 0: 590: 100.00		RHOG_HUMAN (7-193): 2.61e-84: 250: 41.71
+	Hs
		699817 P85A_HUMAN (1-724): 0: 590: 100.00		RND1_HUMAN (6-227): 1.91e-83: 249: 53.15
+	Hs
		466116 P85A_HUMAN (1-724): 0: 590: 100.00		RHOC_HUMAN (9-193): 5.48e-82: 244: 48.11
+	Hs
		580882 P85A_HUMAN (1-724): 0: 590: 100.00		RAC2_HUMAN (8-195): 7.72e-79: 236: 40.43
+	Hs
		699673 P85A_HUMAN (1-724): 0: 590: 100.00		RAC3_HUMAN (8-182): 7.47e-79: 236: 42.86
+	Hs
		699687 P85A_HUMAN (1-724): 0: 590: 100.00		RAC1_HUMAN (8-194): 9.85e-79: 236: 42.25
+	Mm
		686947 P85A_MOUSE (1-724): 0: 585: 95.99		RAC1_MOUSE (8-194): 9.85e-79: 236: 42.25
+	Hs
		136342 P85B_HUMAN (4-719): 2.94e-159: 479: 57.24		RND2_HUMAN (1-227): 6.72e-109: 314: 100.00
+	Hs
		136356 P85B_HUMAN (4-719): 2.94e-159: 479: 57.24		RND3_HUMAN (4-227): 5.97e-99: 289: 64.00
+	Hs
		126468 P85A_HUMAN (1-724): 0: 590: 100.00		RHOD_HUMAN (9-191): 9.06e-55: 176: 43.48
+	Hs
		699862 P85A_HUMAN (1-724): 0: 590: 100.00		RHOF_HUMAN (9-191): 9.2e-51: 165: 43.01
+	Hs
		136360 P85B_HUMAN (4-719): 2.94e-159: 479: 57.24		RHOB_HUMAN (5-185): 8.64e-92: 269: 45.86
+	Hs
		136355 P85B_HUMAN (4-719): 2.94e-159: 479: 57.24		RHOA_HUMAN (9-193): 3.39e-84: 250: 47.03
+	Hs
		136281 P85B_HUMAN (4-719): 2.94e-159: 479: 57.24		RAC2_HUMAN (8-195): 7.72e-79: 236: 40.43
+	Hs
		136352 P85B_HUMAN (4-719): 2.94e-159: 479: 57.24		RAC3_HUMAN (8-182): 7.47e-79: 236: 42.86
+	Hs
		136363 P85B_HUMAN (4-719): 2.94e-159: 479: 57.24		RAC1_HUMAN (8-194): 9.85e-79: 236: 42.25
+	Hs
		126355 P85B_HUMAN (4-719): 2.94e-159: 479: 57.24		RHOD_HUMAN (9-191): 9.06e-55: 176: 43.48