HitPredict

Interactor 1: P85A (P26450)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: Pik3r1

Interactor 2: RAC1 (P63001)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1)
Gene: RAC1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19118901
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010592 - positive regulation of lamellipodium assembly GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Mm			1 192
+	Hs
		699687 P85A_HUMAN (1-724): 0: 553: 94.35		RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00
+	Hs
		580882 P85A_HUMAN (1-724): 0: 553: 94.35		RAC2_HUMAN (1-192): 2.74e-81: 241: 92.19
+	Hs
		699856 P85A_HUMAN (1-724): 0: 553: 94.35		RHOJ_HUMAN (2-189): 1.39e-80: 240: 60.64
+	Hs
		699673 P85A_HUMAN (1-724): 0: 553: 94.35		RAC3_HUMAN (1-191): 3.71e-78: 233: 93.19
+	Hs
		699674 P85A_HUMAN (1-724): 0: 553: 94.35		CDC42_HUMAN (1-192): 5.32e-78: 232: 70.31
+	Hs
		699696 P85A_HUMAN (1-724): 0: 553: 94.35		RHOG_HUMAN (1-192): 1.18e-77: 231: 71.35
+	Hs
		699676 P85A_HUMAN (1-724): 0: 553: 94.35		RHOA_HUMAN (5-192): 1.33e-75: 226: 57.98
+	Hs
		466116 P85A_HUMAN (1-724): 0: 553: 94.35		RHOC_HUMAN (5-192): 3.53e-73: 220: 57.45
+	Hs
		601179 P85A_HUMAN (1-724): 0: 553: 94.35		RHOQ_HUMAN (4-190): 7.78e-73: 220: 63.16
+	Hs
		136363 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00
+	Hs
		136281 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		RAC2_HUMAN (1-192): 2.74e-81: 241: 92.19
+	Hs
		136431 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		RHOJ_HUMAN (2-189): 1.39e-80: 240: 60.64
+	Hs
		136352 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		RAC3_HUMAN (1-191): 3.71e-78: 233: 93.19
+	Hs
		136353 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		CDC42_HUMAN (1-192): 5.32e-78: 232: 70.31
+	Hs
		136368 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		RHOG_HUMAN (1-192): 1.18e-77: 231: 71.35
+	Hs
		136355 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		RHOA_HUMAN (5-192): 1.33e-75: 226: 57.98
+	Hs
		136284 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		RHOQ_HUMAN (4-190): 7.78e-73: 220: 63.16
+	Hs
		962332 P55G_HUMAN (271-723): 3.1e-91: 294: 72.31		RHOA_HUMAN (5-192): 1.33e-75: 226: 57.98
+	Hs
		601391 P55G_HUMAN (271-723): 3.1e-91: 294: 72.31		RHOQ_HUMAN (4-190): 7.78e-73: 220: 63.16
+	Hs
		212765 SRGP3_HUMAN (83-453): 8.56e-70: 249: 15.43		RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00