HitPredict

Interactor 1: MCM7 (P33993)
DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)
Gene: MCM7

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008283 - cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 719 Hs			1 136
+	Mm
		935450 Q3V122_MOUSE (1-719): 0: 789: 92.64		H31_MOUSE (1-136): 3.08e-60: 183: 96.32
+	Mm
		952743 Q3V122_MOUSE (1-719): 0: 789: 92.64		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Hs
		708861 MCM7_HUMAN (1-719): 0: 786: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Mm
		952257 Q3V122_MOUSE (1-719): 0: 789: 92.64		H32_MOUSE (1-136): 5.32e-59: 180: 97.06
+	Hs
		708932 MCM7_HUMAN (1-719): 0: 786: 100.00		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		708603 MCM5_HUMAN (6-716): 0: 682: 27.61		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		708605 MCM5_HUMAN (6-716): 0: 682: 27.61		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		708661 MCM5_HUMAN (6-716): 0: 682: 27.61		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		708690 MCM5_HUMAN (6-716): 0: 682: 27.61		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		708677 MCM5_HUMAN (6-716): 0: 682: 27.61		H37_HUMAN (1-136): 4.54e-57: 175: 94.12
+	Hs
		708683 MCM5_HUMAN (6-716): 0: 682: 27.61		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Sc
		667879 MCM5_YEAST (5-716): 0: 666: 27.77		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Sc
		675545 MCM4_YEAST (7-703): 0: 658: 29.69		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Hs
		832357 MCM2_HUMAN (8-690): 0: 643: 28.13		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		832369 MCM2_HUMAN (8-690): 0: 643: 28.13		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		832495 MCM2_HUMAN (8-690): 0: 643: 28.13		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		832541 MCM2_HUMAN (8-690): 0: 643: 28.13		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Sc
		744787 MCM7_YEAST (2-719): 0: 643: 45.41		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Sc
		675521 MCM4_YEAST (7-703): 0: 658: 29.69		CENPA_YEAST (18-134): 3.39e-40: 135: 56.67
+	Hs
		828172 MCM2_HUMAN (8-690): 0: 643: 28.13		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76