HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: PACN3 (Q9UKS6)
Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)
Gene: PACSIN3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 424
+	Hs
		1147464 EPHA7_HUMAN (4-974): 0: 1120: 50.15		PACN2_HUMAN (4-422): 1.77e-78: 252: 48.96
+	Hs
		931915 EPHA5_HUMAN (11-976): 0: 1115: 51.34		PACN2_HUMAN (4-422): 1.77e-78: 252: 48.96
+	Hs
		932155 EPHA4_HUMAN (1-974): 0: 1110: 50.35		PACN2_HUMAN (4-422): 1.77e-78: 252: 48.96
+	Hs
		710917 EPHB2_HUMAN (28-973): 0: 1077: 48.29		PACN2_HUMAN (4-422): 1.77e-78: 252: 48.96
+	Hs
		710200 EPHA2_HUMAN (1-976): 0: 1124: 100.00		FCHO2_HUMAN (12-369): 1.89e-43: 164: 14.96
+	Hs
		1070496 EPHA7_HUMAN (4-974): 0: 1120: 50.15		FCHO2_HUMAN (12-369): 1.89e-43: 164: 14.96
+	Hs
		931839 EPHA5_HUMAN (11-976): 0: 1115: 51.34		FCHO2_HUMAN (12-369): 1.89e-43: 164: 14.96
+	Hs
		932059 EPHA4_HUMAN (1-974): 0: 1110: 50.35		FCHO2_HUMAN (12-369): 1.89e-43: 164: 14.96
+	Hs
		710552 EPHA2_HUMAN (1-976): 0: 1124: 100.00		BI2L1_HUMAN (50-422): 1.77e-35: 138: 12.53
+	Hs
		1147458 EPHA7_HUMAN (4-974): 0: 1120: 50.15		BI2L1_HUMAN (50-422): 1.77e-35: 138: 12.53
+	Hs
		932150 EPHA4_HUMAN (1-974): 0: 1110: 50.35		BI2L1_HUMAN (50-422): 1.77e-35: 138: 12.53
+	Hs
		710819 EPHB2_HUMAN (28-973): 0: 1077: 48.29		FCHO2_HUMAN (12-369): 1.89e-43: 164: 14.96
+	Hs
		710913 EPHB2_HUMAN (28-973): 0: 1077: 48.29		BI2L1_HUMAN (50-422): 1.77e-35: 138: 12.53
+	Hs
		326852 EPHA4_HUMAN (1-974): 0: 1110: 50.35		RIMB1_HUMAN (277-423): 2.84e-10: 64.8: 18.35
+	Hs
		710840 EPHB2_HUMAN (28-973): 0: 1077: 48.29		ITSN1_HUMAN (346-421): 2.69e-15: 80.6: 28.95
+	Hs
		640319 EPHA1_HUMAN (17-967): 0: 947: 49.28		BI2L1_HUMAN (50-422): 1.77e-35: 138: 12.53
+	Hs
		465502 IGF1R_HUMAN (393-877): 1.45e-133: 437: 29.90		FCHO2_HUMAN (12-369): 1.89e-43: 164: 14.96
+	Rn
		580490 INSR_RAT (371-873): 1.87e-134: 440: 29.49		BI2L1_RAT (50-422): 1.19e-34: 136: 12.53
+	Hs
		463482 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		FCHO2_HUMAN (12-369): 1.89e-43: 164: 14.96
+	Mm
		683098 LYN_MOUSE (607-879): 1.97e-64: 228: 42.91		SRC8_MOUSE (162-421): 2.51e-36: 141: 16.85