HitPredict

Interactor 1: EPHA8 (P29322)
Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK)
Gene: EPHA8

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1005 Hs			1 217
+	Hs
		987657 EPHA7_HUMAN (5-1005): 0: 1178: 56.16		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		931831 EPHA5_HUMAN (2-1001): 0: 1175: 57.21		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		932053 EPHA4_HUMAN (8-1005): 0: 1169: 55.92		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Mm
		932044 EPHB2_MOUSE (31-999): 0: 1166: 50.31		GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54
+	Hs
		840960 EPHA7_HUMAN (5-1005): 0: 1178: 56.16		ABL2_HUMAN (4-139): 9.65e-22: 94.7: 34.04
+	Hs
		593949 EPHA5_HUMAN (2-1001): 0: 1175: 57.21		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		840938 EPHA4_HUMAN (8-1005): 0: 1169: 55.92		ABL2_HUMAN (4-139): 9.65e-22: 94.7: 34.04
+	Mm
		362442 EPHA4_MOUSE (8-1005): 0: 1166: 55.72		ABL1_MOUSE (4-139): 4.08e-22: 95.9: 35.46
+	Hs
		362174 EPHB2_HUMAN (31-999): 0: 1165: 50.20		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Mm
		932042 EPHB2_MOUSE (31-999): 0: 1166: 50.31		ABL2_MOUSE (4-139): 1.56e-20: 91.3: 33.33
+	Hs
		440392 EPHA8_HUMAN (1-1005): 0: 1188: 100.00		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		440461 EPHA5_HUMAN (2-1001): 0: 1175: 57.21		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		440462 EPHA4_HUMAN (8-1005): 0: 1169: 55.92		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		463529 EPHA7_HUMAN (5-1005): 0: 1178: 56.16		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Mm
		813512 EPHA4_MOUSE (8-1005): 0: 1166: 55.72		FYN_MOUSE (161-215): 9.17e-13: 68.5: 31.58
+	Hs
		913632 EPHA4_HUMAN (8-1005): 0: 1169: 55.92		VAV2_HUMAN (3-56): 4.85e-11: 63.5: 38.18
+	Hs
		462999 EPHB2_HUMAN (31-999): 0: 1165: 50.20		YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33
+	Hs
		557189 EPHA4_HUMAN (8-1005): 0: 1169: 55.92		SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58
+	Hs
		463419 EPHA4_HUMAN (8-1005): 0: 1169: 55.92		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Mm
		431334 EPHB2_MOUSE (31-999): 0: 1166: 50.31		SRC_MOUSE (161-215): 3.32e-10: 60.8: 31.58