HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: EPS8 (Q12929)
Epidermal growth factor receptor kinase substrate 8
Gene: EPS8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	7791787
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 822
+	Hs
		1090377 GULP1_HUMAN (137-420): 5.87e-48: 171: 20.00		EPS8_HUMAN (1-822): 0: 994: 100.00
+	Hs
		1090337 SHB_HUMAN (369-579): 1.33e-41: 159: 20.63		EPS8_HUMAN (1-822): 0: 994: 100.00
+	Hs
		711275 SHC1_HUMAN (1-583): 0: 529: 100.00		CRKL_HUMAN (487-662): 3.09e-33: 132: 20.79
+	Hs
		463000 SHC1_HUMAN (1-583): 0: 529: 100.00		YES_HUMAN (448-612): 4.45e-29: 124: 16.00
+	Hs
		440393 SHC1_HUMAN (1-583): 0: 529: 100.00		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Hs
		711274 SHC1_HUMAN (1-583): 0: 529: 100.00		CRK_HUMAN (487-661): 8.46e-28: 116: 18.75
+	Mm
		1000059 ANS1B_MOUSE (39-361): 8.03e-51: 191: 19.41		STAM1_MOUSE (458-783): 5.64e-51: 189: 15.11
+	Hs
		584523 VAV_HUMAN (154-578): 2.52e-55: 202: 11.97		BTK_HUMAN (422-701): 9.03e-28: 121: 10.77
+	Hs
		440335 VAV_HUMAN (154-578): 2.52e-55: 202: 11.97		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Hs
		584490 VAV_HUMAN (154-578): 2.52e-55: 202: 11.97		CRK_HUMAN (487-661): 8.46e-28: 116: 18.75
+	Mm
		1223181 ANS1B_MOUSE (39-361): 8.03e-51: 191: 19.41		PACN1_MOUSE (435-586): 2.48e-27: 118: 17.53
+	Hs
		473402 HCK_HUMAN (348-575): 6.63e-42: 160: 17.16		BTK_HUMAN (422-701): 9.03e-28: 121: 10.77
+	Hs
		597885 FER_HUMAN (345-581): 4.36e-41: 161: 18.75		CRK_HUMAN (487-661): 8.46e-28: 116: 18.75
+	Hs
		855632 SHB_HUMAN (369-579): 1.33e-41: 159: 20.63		CRK_HUMAN (487-661): 8.46e-28: 116: 18.75
+	Mm
		813529 NCK1_MOUSE (360-575): 2.05e-41: 155: 18.30		FYN_MOUSE (454-613): 2e-27: 119: 16.57
+	Hs
		222130 ANS1B_HUMAN (39-362): 4.12e-51: 191: 17.18		NCK2_HUMAN (535-612): 1.03e-12: 72.7: 24.69
+	Hs
		222014 NCK2_HUMAN (363-579): 7.09e-45: 165: 18.83		NCK1_HUMAN (536-621): 1.03e-18: 90.8: 30.23
+	Hs
		222176 SHD_HUMAN (328-582): 1.37e-47: 171: 23.02		NCK2_HUMAN (535-612): 1.03e-12: 72.7: 24.69
+	Hs
		221982 NCK2_HUMAN (363-579): 7.09e-45: 165: 18.83		NCK2_HUMAN (535-612): 1.03e-12: 72.7: 24.69
+	Hs
		222088 SHB_HUMAN (369-579): 1.33e-41: 159: 20.63		NCK2_HUMAN (535-612): 1.03e-12: 72.7: 24.69