HitPredict

Interactor 1: PML (P29590)
Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)
Gene: PML

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34795231, 36880596
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0016925 - protein sumoylation GO:0019789 - SUMO transferase activity
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 882 Hs			1 628
+	Hs
		297465 PML_HUMAN (1-882): 0: 902: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		297758 PML_HUMAN (1-882): 0: 902: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		714266 PML_HUMAN (1-882): 0: 902: 100.00		PIAS4_HUMAN (2-477): 2.12e-177: 514: 46.71
+	Hs
		1420194 TRIM8_HUMAN (51-539): 2.04e-66: 233: 14.77		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		1419346 TRI55_HUMAN (48-500): 1.34e-50: 189: 13.07		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		297685 TRIM5_HUMAN (48-444): 4.78e-57: 206: 12.65		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		297684 TRI55_HUMAN (48-500): 1.34e-50: 189: 13.07		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		297864 TRI55_HUMAN (48-500): 1.34e-50: 189: 13.07		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		180870 TIF1A_HUMAN (27-546): 6.85e-61: 226: 16.49		PIAS4_HUMAN (2-477): 2.12e-177: 514: 46.71
+	Hs
		1100526 TIF1B_HUMAN (7-593): 4.28e-70: 250: 14.24		ZMIZ1_HUMAN (79-422): 1.83e-84: 287: 24.93