HitPredict

Interactor 1: MMP12 (P34960)
Macrophage metalloelastase (MME) (EC 3.4.24.65) (Matrix metalloproteinase-12) (MMP-12)
Gene: MMP12

Interactor 2: CXCL5 (P50228)
C-X-C motif chemokine 5 (Cytokine LIX) (Small-inducible cytokine B5) [Cleaved into: GCP-2(1-78); GCP-2(9-78)]
Gene: CXCL5

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18660381
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 473 Mm			1 132
+	Hs
		764724 MMP12_HUMAN (12-473): 0: 646: 61.57		CXCL5_HUMAN (32-117): 5.91e-32: 110: 54.65
+	Mm
		500671 MMP12_MOUSE (1-473): 0: 646: 100.00		CXCL2_MOUSE (43-115): 4.91e-29: 103: 52.06
+	Mm
		522396 MMP12_MOUSE (1-473): 0: 646: 100.00		GROA_MOUSE (43-116): 4.06e-29: 103: 50.00
+	Hs
		364043 MMP12_HUMAN (12-473): 0: 646: 61.57		CXCL7_HUMAN (47-116): 1.16e-27: 100: 52.86
+	Hs
		587770 MMP12_HUMAN (12-473): 0: 646: 61.57		CXCL2_HUMAN (43-116): 8.59e-28: 100: 44.60
+	Mm
		714631 MMP12_MOUSE (1-473): 0: 646: 100.00		CXCL3_MOUSE (43-117): 1.27e-27: 99.8: 45.33
+	Hs
		587787 MMP12_HUMAN (12-473): 0: 646: 61.57		CXCL3_HUMAN (47-115): 2.91e-27: 99: 46.38
+	Hs
		448989 MMP12_HUMAN (12-473): 0: 646: 61.57		GROA_HUMAN (47-116): 1.25e-26: 97.5: 51.43
+	Hs
		764727 MMP12_HUMAN (12-473): 0: 646: 61.57		CXCL6_HUMAN (39-117): 3.77e-26: 96.3: 63.29
+	Hs
		486188 MMP12_HUMAN (12-473): 0: 646: 61.57		IL8_HUMAN (48-117): 4.37e-24: 90.5: 36.62
+	Hs
		372733 MMP1_HUMAN (32-473): 0: 612: 45.60		CXCL5_HUMAN (32-117): 5.91e-32: 110: 54.65
+	Hs
		486190 MMP13_HUMAN (15-473): 0: 630: 43.83		IL8_HUMAN (48-117): 4.37e-24: 90.5: 36.62
+	Hs
		612139 MMP8_HUMAN (23-473): 0: 605: 43.74		CXCL5_HUMAN (32-117): 5.91e-32: 110: 54.65
+	Hs
		364034 MMP1_HUMAN (32-473): 0: 612: 45.60		CXCL7_HUMAN (47-116): 1.16e-27: 100: 52.86
+	Hs
		372731 MMP1_HUMAN (32-473): 0: 612: 45.60		CXCL2_HUMAN (43-116): 8.59e-28: 100: 44.60
+	Hs
		372737 MMP1_HUMAN (32-473): 0: 612: 45.60		CXCL6_HUMAN (39-117): 3.77e-26: 96.3: 63.29
+	Hs
		372724 MMP1_HUMAN (32-473): 0: 612: 45.60		IL8_HUMAN (48-117): 4.37e-24: 90.5: 36.62
+	Hs
		486182 MMP8_HUMAN (23-473): 0: 605: 43.74		IL8_HUMAN (48-117): 4.37e-24: 90.5: 36.62
+	Hs
		364037 MMP9_HUMAN (31-210): 7.08e-68: 231: 43.33		CXCL7_HUMAN (47-116): 1.16e-27: 100: 52.86
+	Hs
		486175 MMP9_HUMAN (31-210): 7.08e-68: 231: 43.33		IL8_HUMAN (48-117): 4.37e-24: 90.5: 36.62