HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: INGR2 (P38484)
Interferon gamma receptor 2 (IFN-gamma receptor 2) (IFN-gamma-R2) (Interferon gamma receptor accessory factor 1) (AF-1) (Interferon gamma receptor beta-chain) (IFN-gamma-R-beta) (Interferon gamma transducer 1)
Gene: IFNGR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	7673114
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001774 - microglial cell activation GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway GO:0060333 - type II interferon-mediated signaling pathway GO:0098586 - cellular response to virus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Hs			1 337
+	Mm
		1223792 JAK2_MOUSE (1-1129): 0: 1103: 93.89		Q63953_MOUSE (16-336): 1.04e-104: 311: 58.51
+	Mm
		582215 JAK2_MOUSE (1-1129): 0: 1103: 93.89		INGR1_MOUSE (1-327): 4.09e-63: 209: 16.07
+	Hs
		253285 JAK2_HUMAN (1-1132): 0: 1116: 100.00		INGR1_HUMAN (27-332): 1.55e-43: 158: 16.57
+	Hs
		253289 JAK2_HUMAN (1-1132): 0: 1116: 100.00		PRLR_HUMAN (28-287): 1.16e-09: 61.5: 16.91
+	Mm
		1025675 JAK2_MOUSE (1-1129): 0: 1103: 93.89		IL6RB_MOUSE (25-246): 8.53e-11: 65: 16.96
+	Hs
		714630 TYK2_HUMAN (38-1132): 0: 861: 35.49		INLR1_HUMAN (30-237): 3.49e-41: 152: 16.04
+	Hs
		602867 TYK2_HUMAN (38-1132): 0: 861: 35.49		INAR1_HUMAN (1-253): 5.04e-25: 107: 21.48
+	Hs
		557062 SRC_HUMAN (803-1131): 9.13e-99: 325: 25.15		INGR1_HUMAN (27-332): 1.55e-43: 158: 16.57
+	Hs
		710107 ABL2_HUMAN (821-1129): 4.58e-95: 331: 31.61		EPHA2_HUMAN (32-229): 1.93e-09: 61.1: 19.50
+	Hs
		557119 SRC_HUMAN (803-1131): 9.13e-99: 325: 25.15		EPHA2_HUMAN (32-229): 1.93e-09: 61.1: 19.50
+	Hs
		462998 YES_HUMAN (805-1125): 2.21e-97: 322: 27.02		EPHA2_HUMAN (32-229): 1.93e-09: 61.1: 19.50
+	Hs
		439965 LCK_HUMAN (827-1132): 1.51e-97: 321: 30.62		EPHA2_HUMAN (32-229): 1.93e-09: 61.1: 19.50
+	Hs
		463358 LYN_HUMAN (807-1132): 4.35e-93: 309: 30.89		EPHA2_HUMAN (32-229): 1.93e-09: 61.1: 19.50
+	Hs
		658659 JAK1_HUMAN (793-1131): 9.56e-37: 153: 18.44		INAR2_HUMAN (10-330): 3.21e-62: 208: 15.85
+	Hs
		658722 JAK1_HUMAN (793-1131): 9.56e-37: 153: 18.44		I20RB_HUMAN (1-329): 8.69e-64: 206: 23.72
+	Hs
		658701 JAK1_HUMAN (793-1131): 9.56e-37: 153: 18.44		I10R1_HUMAN (28-313): 8.87e-58: 197: 18.46
+	Hs
		582134 JAK1_HUMAN (793-1131): 9.56e-37: 153: 18.44		INGR1_HUMAN (27-332): 1.55e-43: 158: 16.57
+	Hs
		658731 JAK1_HUMAN (793-1131): 9.56e-37: 153: 18.44		INLR1_HUMAN (30-237): 3.49e-41: 152: 16.04
+	Hs
		602862 JAK1_HUMAN (793-1131): 9.56e-37: 153: 18.44		INAR1_HUMAN (1-253): 5.04e-25: 107: 21.48
+	Hs
		411419 NTRK1_HUMAN (526-808): 1.64e-20: 99.8: 24.59		EPHA2_HUMAN (32-229): 1.93e-09: 61.1: 19.50