Protein: JAK2
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)

Gene: JAK2
Organism: Mus musculus
Interactions: 46
UniProt ID: Q62120

Gene Ontology (top 5):
GO:0000791 - euchromatin
GO:0001774 - microglial cell activation
GO:0002250 - adaptive immune response
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

838288

STAT3
Signal transducer and activator of transcription 3

4

20

Small-scale

0.878

High

575632

EPOR
Erythropoietin receptor

3

20

Small-scale

0.827

High

1223791

JAK2
Tyrosine-protein kinase JAK2

3

19

Small-scale

0.818

High

205468

SOCS3
Suppressor of cytokine signaling 3

2

20

Small-scale

0.799

High

205433

SOCS1
Suppressor of cytokine signaling 1

2

20

Small-scale

0.786

High

1223795

SH2B1
SH2B adapter protein 1

2

20

Small-scale

0.777

High

838420

STA5B
Signal transducer and activator of transcription 5B

2

20

Small-scale

0.768

High

1030070

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.768

High

686971

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.754

High

1223793

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

Small-scale

0.724

High

871460

LEPR
Leptin receptor

1

20

Small-scale

0.665

High

236702

SOCS5
Suppressor of cytokine signaling 5

1

20

Small-scale

0.647

High

148425

PKD1
Polycystin-1

1

16

Small-scale

0.618

High

148583

SH2B3
SH2B adapter protein 3

1

20

Small-scale

0.618

High

431356

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

431460

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.618

High

711227

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

20

Small-scale

0.618

High

777179

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

Small-scale

0.618

High

838408

STA5A
Signal transducer and activator of transcription 5A

1

20

Small-scale

0.618

High

1021266

I12R2
Interleukin-12 receptor subunit beta-2

1

20

Small-scale

0.618

High

1048195

YES
Tyrosine-protein kinase Yes

1

19

Small-scale

0.618

High

1223792

Q63953
Ifngr2 protein

2

20

Small-scale

0.601

High

1063037

TPOR
Thrombopoietin receptor

2

7

Small-scale

0.584

High

767018

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.575

High

1000057

STAM1
Signal transducing adapter molecule 1

1

20

Small-scale

0.575

High

1021897

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

17

Small-scale

0.561

High

1223794

CRLF2
Cytokine receptor-like factor 2

2

20

Small-scale

0.533

High

1025675

IL6RB
Interleukin-6 receptor subunit beta

1

20

Small-scale

0.527

High

857024

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

8

Small-scale

0.515

High

1022219

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.492

High

147393

S1PR1
Sphingosine 1-phosphate receptor 1

1

11

Small-scale

0.479

High

582215

INGR1
Interferon gamma receptor 1

1

16

Small-scale

0.479

High

599257

GHR
Growth hormone receptor

1

20

Small-scale

0.479

High

633287

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

6

Small-scale

0.479

High

689975

IL3RA
Interleukin-3 receptor subunit alpha

1

20

Small-scale

0.479

High

689977

IL3B2
Interleukin-3 receptor class 2 subunit beta

1

20

Small-scale

0.479

High

689979

IL3RB
Cytokine receptor common subunit beta

1

20

Small-scale

0.479

High

890924

CAV1
Caveolin-1

1

11

Small-scale

0.479

High

965535

LMO4
LIM domain transcription factor LMO4

1

19

Small-scale

0.479

High

1064402

PRLR
Prolactin receptor

1

20

Small-scale

0.479

High

1223796

S40A1
Ferroportin

1

0

Small-scale

0.458

High

1223797

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

High-throughput

0.457

High

450401

CSF1
Macrophage colony-stimulating factor 1

1

12

Small-scale

0.445

High

449219

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

20

Small-scale

0.436

High

1014283

ELOC
Elongin-C

1

0

Small-scale

0.426

High


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Last updated: 11Aug2025