HitPredict

Interactor 1: PHB1 (P35232)
Prohibitin 1
Gene: PHB1

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	29426014
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0050847 - progesterone receptor signaling pathway GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 272 Hs			1 875
+	Hs
		125187 PHB1_HUMAN (1-272): 7.06e-92: 274: 100.00		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		719065 PHB1_HUMAN (1-272): 7.06e-92: 274: 100.00		ITCH_HUMAN (325-873): 0: 579: 24.78
+	Hs
		125668 PHB2_HUMAN (6-267): 1.38e-85: 259: 50.57		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		1305252 PHB2_HUMAN (6-267): 1.38e-85: 259: 50.57		WWP1_HUMAN (185-873): 0: 560: 22.22
+	Hs
		718957 PHB1_HUMAN (1-272): 7.06e-92: 274: 100.00		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		1192182 PHB2_HUMAN (6-267): 1.38e-85: 259: 50.57		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97