HitPredict

Interactor 1: B3KSH4 (B3KSH4)
Huntingtin interacting protein 2, isoform CRA_a (cDNA FLJ36214 fis, clone THYMU2000672, highly similar to Ubiquitin-conjugating enzyme E2-25 kDa)
Gene: HIP2

Interactor 2: CBLC (Q9ULV8)
E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C)
Gene: CBLC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.80	0.528

Property	Details
Experiments	19549727
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cbl_N~UQ_con, UQ_con~zf-C3HC4_3
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 97 Hs			1 474
+	Hs
		919717 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		CBLB_HUMAN (4-471): 0: 704: 41.18
+	Hs
		896396 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		CBLC_HUMAN (1-474): 0: 687: 100.00
+	Hs
		610333 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		CBL_HUMAN (11-473): 0: 695: 42.14
+	Hs
		610323 UB2D3_HUMAN (1-51): 6.77e-29: 102: 35.29		CBL_HUMAN (11-473): 0: 695: 42.14
+	Hs
		919905 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		CBLC_HUMAN (1-474): 0: 687: 100.00
+	Xl
		1140146 Q8AVM8_XENLA (1-97): 4.07e-34: 117: 96.91		Q5XGX4_XENLA (343-450): 5.67e-31: 119: 28.18
+	Hs
		896353 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		RN185_HUMAN (344-450): 1.35e-30: 119: 28.44
+	Hs
		72152 B3KSH4_HUMAN (1-97): 7.05e-34: 113: 100.00		RN185_HUMAN (344-450): 1.35e-30: 119: 28.44
+	Dm
		854587 UBCD4_DROME (1-96): 7.84e-33: 114: 56.25		Q8IR26_DROME (329-449): 4.25e-29: 117: 22.76
+	Dm
		854593 UBCD4_DROME (1-96): 7.84e-33: 114: 56.25		Q9VXP1_DROME (329-449): 4.43e-29: 117: 22.76
+	Hs
		896364 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		RNF5_HUMAN (345-450): 3.86e-29: 114: 21.30
+	Hs
		72156 B3KSH4_HUMAN (1-97): 7.05e-34: 113: 100.00		RNF5_HUMAN (345-450): 3.86e-29: 114: 21.30
+	At
		715141 UBC9_ARATH (1-52): 5.9e-29: 103: 38.46		Q9LN67_ARATH (349-441): 5.76e-32: 123: 28.13
+	Hs
		919826 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		RN185_HUMAN (344-450): 1.35e-30: 119: 28.44
+	Dm
		854586 UBCD4_DROME (1-96): 7.84e-33: 114: 56.25		Q8IQM1_DROME (345-442): 1.84e-27: 109: 25.00
+	Dm
		639398 UBCD1_DROME (1-51): 1.57e-29: 104: 39.22		Q8IR26_DROME (329-449): 4.25e-29: 117: 22.76
+	Dm
		639411 UBCD1_DROME (1-51): 1.57e-29: 104: 39.22		Q9VXP1_DROME (329-449): 4.43e-29: 117: 22.76
+	Hs
		895880 UB2D3_HUMAN (1-51): 6.77e-29: 102: 35.29		RN185_HUMAN (344-450): 1.35e-30: 119: 28.44
+	Hs
		919838 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		RNF5_HUMAN (345-450): 3.86e-29: 114: 21.30
+	Hs
		895892 UB2D3_HUMAN (1-51): 6.77e-29: 102: 35.29		RNF5_HUMAN (345-450): 3.86e-29: 114: 21.30