HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: GSK3B (P49841)
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Gene: GSK3B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 15688030, 18505846, 8524413, 17428466, 14701753, 22337773, 27563096, 29464284, 16009706, 30517763, 37490552, 19995607, 16123141, 15470047, 20856200, 14645548, 20682768, 19713527, 23824745, 16282323 and 2 others

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Identification Methods enzymatic study, affinity chromatography technology, pull down, protein kinase assay, in-gel kinase assay, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 21 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 480
Hs

1 420
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+ Ce
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Last updated: 11Aug2025