HitPredict

Interactor 1: RPN1 (P38764)
26S proteasome regulatory subunit RPN1 (HMG-CoA reductase degradation protein 2) (Proteasome non-ATPase subunit 1)
Gene: RPN1

Interactor 2: PSA4 (P40303)
Proteasome subunit alpha type-4 (Macropain subunit PRE6) (Multicatalytic endopeptidase complex subunit PRE6) (Proteasome component PRE6) (Proteinase YSCE subunit PRE6)
Gene: PRE6

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	16429126, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 993 Sc			1 254
+	Hs
		156281 PSMD2_HUMAN (2-989): 0: 1010: 34.61		PSA7_HUMAN (4-234): 3.74e-95: 280: 58.01
+	Hs
		638122 PSMD2_HUMAN (2-989): 0: 1010: 34.61		PSA4_HUMAN (3-233): 8.68e-91: 270: 31.49
+	Hs
		893662 PSMD2_HUMAN (2-989): 0: 1010: 34.61		PSA6_HUMAN (2-239): 6.82e-91: 270: 29.75
+	Hs
		637407 PSMD2_HUMAN (2-989): 0: 1010: 34.61		PSA1_HUMAN (2-249): 6.06e-90: 268: 31.35
+	Hs
		656214 PSMD2_HUMAN (2-989): 0: 1010: 34.61		PSA5_HUMAN (2-236): 2.2e-90: 268: 32.92
+	Sc
		619357 RPN1_YEAST (1-993): 0: 1053: 100.00		PSA3_YEAST (4-207): 3.34e-40: 140: 35.29
+	Hs
		637679 PSMD2_HUMAN (2-989): 0: 1010: 34.61		PSA2_HUMAN (3-236): 1.56e-45: 154: 38.14
+	Sp
		953206 RPN1_SCHPO (5-988): 0: 871: 37.71		PSA4_SCHPO (1-252): 1.7e-93: 277: 55.95
+	Sp
		953217 RPN1_SCHPO (5-988): 0: 871: 37.71		PSA5_SCHPO (2-239): 2.2e-93: 276: 36.48
+	Sp
		953201 RPN1_SCHPO (5-988): 0: 871: 37.71		PSA3_SCHPO (1-243): 1.64e-92: 274: 32.93
+	Sp
		293713 RPN1_SCHPO (5-988): 0: 871: 37.71		PSA2_SCHPO (4-236): 5.42e-40: 140: 39.11
+	Dm
		1278652 Q9VW54_DROME (1-989): 0: 738: 33.30		PSA5_DROME (2-237): 3.02e-91: 270: 31.28
+	Dm
		611672 Q9VW54_DROME (1-989): 0: 738: 33.30		PSA71_DROME (2-233): 1.09e-88: 264: 51.72
+	Hs
		156342 PSMD1_HUMAN (52-925): 0: 709: 13.42		PSA7_HUMAN (4-234): 3.74e-95: 280: 58.01
+	Hs
		638180 PSMD1_HUMAN (52-925): 0: 709: 13.42		PSA4_HUMAN (3-233): 8.68e-91: 270: 31.49
+	Hs
		893734 PSMD1_HUMAN (52-925): 0: 709: 13.42		PSA6_HUMAN (2-239): 6.82e-91: 270: 29.75
+	Hs
		637529 PSMD1_HUMAN (52-925): 0: 709: 13.42		PSA1_HUMAN (2-249): 6.06e-90: 268: 31.35
+	Hs
		656297 PSMD1_HUMAN (52-925): 0: 709: 13.42		PSA5_HUMAN (2-236): 2.2e-90: 268: 32.92
+	Dm
		771325 Q9VW54_DROME (1-989): 0: 738: 33.30		PSA2_DROME (4-214): 9.25e-44: 149: 40.28
+	Hs
		637734 PSMD1_HUMAN (52-925): 0: 709: 13.42		PSA2_HUMAN (3-236): 1.56e-45: 154: 38.14