HitPredict

Interactor 1: B3KSH4 (B3KSH4)
Huntingtin interacting protein 2, isoform CRA_a (cDNA FLJ36214 fis, clone THYMU2000672, highly similar to Ubiquitin-conjugating enzyme E2-25 kDa)
Gene: HIP2

Interactor 2: R144A (P50876)
E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4)
Gene: RNF144A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.80	0.528

Property	Details
Experiments	19549727
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	IBR_1~UQ_con
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 97 Hs			1 292
+	Hs
		898212 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		R144A_HUMAN (1-292): 3.15e-99: 294: 100.00
+	Hs
		898218 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		R144A_HUMAN (1-292): 3.15e-99: 294: 100.00
+	Hs
		982336 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		RN19A_HUMAN (17-276): 1.42e-75: 248: 25.09
+	Hs
		982216 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		RN19B_HUMAN (13-276): 7.98e-74: 241: 25.54
+	Hs
		957106 UB2D3_HUMAN (1-51): 1.04e-29: 105: 35.29		RN19B_HUMAN (13-276): 7.98e-74: 241: 25.54
+	Hs
		335073 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		ARI2_HUMAN (2-231): 1.36e-67: 219: 25.53
+	Hs
		335048 UB2D3_HUMAN (1-51): 1.04e-29: 105: 35.29		ARI2_HUMAN (2-231): 1.36e-67: 219: 25.53
+	Hs
		957255 UB2D3_HUMAN (1-51): 1.04e-29: 105: 35.29		ARI1_HUMAN (15-229): 5.85e-67: 219: 27.48
+	Hs
		335203 UB2D4_HUMAN (1-51): 1.2e-29: 104: 39.22		ARI2_HUMAN (2-231): 1.36e-67: 219: 25.53
+	Hs
		982351 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		RNF14_HUMAN (14-239): 2.69e-61: 203: 22.93
+	Dm
		683049 UBCD1_DROME (1-51): 3.1e-30: 106: 39.22		LUBEL_DROME (19-225): 5.5e-58: 202: 22.22
+	Hs
		957225 UB2D3_HUMAN (1-51): 1.04e-29: 105: 35.29		RNF14_HUMAN (14-239): 2.69e-61: 203: 22.93
+	Hs
		957644 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		RNF31_HUMAN (19-224): 2.97e-49: 176: 22.62
+	Hs
		982279 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		RNF31_HUMAN (19-224): 2.97e-49: 176: 22.62
+	Hs
		957160 UB2D3_HUMAN (1-51): 1.04e-29: 105: 35.29		RNF31_HUMAN (19-224): 2.97e-49: 176: 22.62
+	Mm
		957266 UB2D3_MOUSE (1-51): 1.04e-29: 105: 35.29		RNF31_MOUSE (19-218): 3.54e-49: 176: 23.26
+	Hs
		1389430 UB2D4_HUMAN (1-51): 1.2e-29: 104: 39.22		RNF31_HUMAN (19-224): 2.97e-49: 176: 22.62
+	Hs
		982338 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		RN216_HUMAN (17-219): 3.85e-12: 68.6: 27.54
+	Hs
		957215 UB2D3_HUMAN (1-51): 1.04e-29: 105: 35.29		RN216_HUMAN (17-219): 3.85e-12: 68.6: 27.54
+	Hs
		1451196 UB2D4_HUMAN (1-51): 1.2e-29: 104: 39.22		RN216_HUMAN (17-219): 3.85e-12: 68.6: 27.54