HitPredict

Interactor 1: B3KSH4 (B3KSH4)
Huntingtin interacting protein 2, isoform CRA_a (cDNA FLJ36214 fis, clone THYMU2000672, highly similar to Ubiquitin-conjugating enzyme E2-25 kDa)
Gene: HIP2

Interactor 2: DTX3L (Q8TDB6)
E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)
Gene: DTX3L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.80	0.528

Property	Details
Experiments	19549727
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 97 Hs			1 740
+	Hs
		957632 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		DTX3L_HUMAN (1-740): 0: 1213: 100.00
+	Hs
		982257 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		DTX3L_HUMAN (1-740): 0: 1213: 100.00
+	Hs
		957143 UB2D3_HUMAN (1-51): 1.04e-29: 105: 35.29		DTX3L_HUMAN (1-740): 0: 1213: 100.00
+	Hs
		1350958 UB2D4_HUMAN (1-51): 1.2e-29: 104: 39.22		DTX3L_HUMAN (1-740): 0: 1213: 100.00
+	Hs
		906716 UB2D1_HUMAN (1-51): 2.38e-29: 103: 39.22		DTX3L_HUMAN (1-740): 0: 1213: 100.00
+	Hs
		982233 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		DTX1_HUMAN (490-739): 3.17e-121: 378: 33.70
+	Hs
		982229 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		DTX2_HUMAN (490-739): 9.98e-121: 377: 37.14
+	Hs
		957126 UB2D3_HUMAN (1-51): 1.04e-29: 105: 35.29		DTX1_HUMAN (490-739): 3.17e-121: 378: 33.70
+	Hs
		1294448 UB2D4_HUMAN (1-51): 1.2e-29: 104: 39.22		DTX1_HUMAN (490-739): 3.17e-121: 378: 33.70
+	Hs
		957122 UB2D3_HUMAN (1-51): 1.04e-29: 105: 35.29		DTX2_HUMAN (490-739): 9.98e-121: 377: 37.14
+	Hs
		1289342 UB2D4_HUMAN (1-51): 1.2e-29: 104: 39.22		DTX2_HUMAN (490-739): 9.98e-121: 377: 37.14
+	Hs
		906697 UB2D1_HUMAN (1-51): 2.38e-29: 103: 39.22		DTX1_HUMAN (490-739): 3.17e-121: 378: 33.70
+	Hs
		906692 UB2D1_HUMAN (1-51): 2.38e-29: 103: 39.22		DTX2_HUMAN (490-739): 9.98e-121: 377: 37.14
+	Hs
		957781 UBE2N_HUMAN (1-51): 3.48e-24: 90.8: 50.98		DTX1_HUMAN (490-739): 3.17e-121: 378: 33.70
+	Hs
		957629 UBE2K_HUMAN (1-97): 6.08e-34: 117: 100.00		DTX3_HUMAN (552-739): 8.69e-95: 300: 54.45
+	Hs
		75517 B3KSH4_HUMAN (1-97): 3.95e-34: 114: 100.00		DTX3_HUMAN (552-739): 8.69e-95: 300: 54.45
+	Hs
		982247 UB2D2_HUMAN (1-51): 8.37e-31: 107: 39.22		DTX3_HUMAN (552-739): 8.69e-95: 300: 54.45
+	Hs
		957133 UB2D3_HUMAN (1-51): 1.04e-29: 105: 35.29		DTX3_HUMAN (552-739): 8.69e-95: 300: 54.45
+	Hs
		1331925 UB2D4_HUMAN (1-51): 1.2e-29: 104: 39.22		DTX3_HUMAN (552-739): 8.69e-95: 300: 54.45
+	Hs
		906708 UB2D1_HUMAN (1-51): 2.38e-29: 103: 39.22		DTX3_HUMAN (552-739): 8.69e-95: 300: 54.45