HitPredict

Interactor 1: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 33961781, 35384245, 21875946
Identification Methods affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CDC37_M~PK_Tyr_Ser-Thr, CDC37_N~PK_Tyr_Ser-Thr
Common GO terms GO:0005737 - cytoplasm
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 607
Hs

1 378
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Service provided by Combinatics, Japan

Last updated: 11Aug2025