HitPredict

Interactor 1: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	31980649, 35384245, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC37_M~PK_Tyr_Ser-Thr, CDC37_N~PK_Tyr_Ser-Thr
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Hs			1 378
+	Hs
		710632 EPHA3_HUMAN (2-810): 0: 656: 19.95		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		932079 EPHA4_HUMAN (2-836): 0: 645: 19.10		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		1147331 EPHA7_HUMAN (2-833): 0: 626: 19.48		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		1158586 EPHA6_HUMAN (2-834): 0: 626: 18.28		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		932034 EPHB1_HUMAN (2-833): 0: 626: 20.59		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		931856 EPHA5_HUMAN (2-812): 0: 625: 20.50		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		710842 EPHB2_HUMAN (2-821): 0: 618: 19.70		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		710267 EPHA2_HUMAN (1-843): 0: 616: 19.51		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		710711 EPHA8_HUMAN (2-824): 0: 600: 18.82		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		1088185 MERTK_HUMAN (6-861): 0: 588: 40.25		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		640176 EPHA1_HUMAN (1-843): 0: 561: 20.38		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		931950 EPHB4_HUMAN (2-836): 0: 558: 20.52		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		1038439 TIE2_HUMAN (16-809): 1.46e-164: 511: 24.34		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		641182 FGFR2_HUMAN (17-859): 1.11e-164: 502: 21.57		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		773350 TIE1_HUMAN (16-809): 3.41e-159: 497: 22.46		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		439746 INSR_HUMAN (272-851): 3.88e-136: 441: 27.97		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		472071 MET_HUMAN (536-799): 3.43e-66: 243: 45.90		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		1049157 RON_HUMAN (518-810): 1.37e-56: 214: 40.47		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		477236 ROS1_HUMAN (284-804): 1.68e-56: 214: 31.27		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		1051003 FAK1_HUMAN (527-851): 1.73e-56: 213: 36.83		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00