HitPredict

Interactor 1: EZ (P42124)
Histone-lysine N-methyltransferase E(z) (EC 2.1.1.356) (Lysine N-methyltransferase 6) (Protein enhancer of zeste)
Gene: E(z)

Interactor 2: CAF1 (Q24572)
Chromatin assembly factor 1 p55 subunit (CAF-1 p55 subunit) (CAF-1) (Nucleosome-remodeling factor 55 kDa subunit) (NURF-55)
Gene: Caf1-55

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.962

The method score is based on:

Property Details
Experiments 11124122, 12408863, 26063573, 15776017, 19767730, 18276122, 12533794, 17762866
Identification Methods pull down, affinity chromatography technology, tandem affinity purification
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains SET~WD40
Common GO terms GO:0005634 - nucleus
GO:0031507 - heterochromatin formation
GO:0035097 - histone methyltransferase complex
GO:0035098 - ESC/E(Z) complex
GO:0045892 - negative regulation of DNA-templated transcription
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 760
Dm

1 430
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+ At
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+ Ce
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024