HitPredict

Interactor 1: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Interactor 2: PTPRS (Q13332)
Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
Gene: PTPRS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38117590
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2-set_2~I-set, C2-set_2~Ig_3, Ig_3~fn3, Ig_3~I-set, Ig_3~Ig_3, V-set~fn3, I-set~V-set, Ig_3~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 1948
+	Hs
		489921 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		PTPRF_HUMAN (1-1948): 0: 1528: 65.42
+	Hs
		576997 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		PTPRA_HUMAN (1176-1948): 0: 815: 39.54
+	Hs
		617087 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		PTPRG_HUMAN (858-1945): 0: 786: 25.86
+	Gg
		47583 CNTN1_CHICK (16-618): 6.28e-65: 233: 12.99		A0A8V0YWD3_CHICK (1185-1948): 0: 822: 40.57
+	Mm
		530202 NCAM1_MOUSE (255-646): 5.9e-53: 198: 14.98		PTPRA_MOUSE (1168-1948): 0: 802: 37.59
+	Hs
		793291 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		PTPRJ_HUMAN (1651-1945): 1.75e-106: 375: 37.29
+	Mm
		1186724 PTK7_MOUSE (141-613): 9.65e-54: 201: 15.07		Q7TQG5_MOUSE (3-931): 2.65e-106: 377: 19.98
+	Mm
		1167062 DSCAM_MOUSE (265-506): 3.08e-09: 62.4: 25.38		SDK2_MOUSE (3-1422): 7.14e-122: 430: 16.41
+	Hs
		793317 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		PTPRK_HUMAN (113-670): 1.42e-10: 68.9: 15.72
+	Hs
		660833 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		PTPRM_HUMAN (33-462): 1.68e-09: 65.4: 12.86
+	Hs
		1264775 TITIN_HUMAN (50-634): 4.44e-11: 68.6: 11.22		NEO1_HUMAN (322-1447): 6.5e-95: 341: 13.80
+	Hs
		617163 CNTN1_HUMAN (19-642): 1.11e-44: 173: 13.26		PTPRZ_HUMAN (1387-1668): 4.97e-47: 189: 27.21
+	Hs
		616914 CNTN1_HUMAN (19-642): 1.11e-44: 173: 13.26		PTPRB_HUMAN (257-1309): 2.07e-37: 157: 12.51
+	Hs
		1069952 PXDN_HUMAN (183-555): 5.6e-61: 222: 20.77		PTPRK_HUMAN (113-670): 1.42e-10: 68.9: 15.72
+	Dm
		1308480 Q9BN17_DROME (25-345): 8.9e-21: 99.6: 16.42		Q9W4F5_DROME (460-1462): 4.19e-47: 189: 14.46
+	Dm
		561765 Q9VPZ7_DROME (429-643): 1.17e-21: 102: 12.83		PTP69_DROME (44-540): 2.55e-17: 91.2: 13.64