HitPredict

Interactor 1: KI2L1 (P43626)
Killer cell immunoglobulin-like receptor 2DL1 (CD158 antigen-like family member A) (Natural killer-associated transcript 1) (NKAT-1) (p58 natural killer cell receptor clones CL-42/47.11) (p58 NK receptor CL-42/47.11) (p58.1 MHC class-I-specific NK receptor) (CD antigen CD158a)
Gene: KIR2DL1

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.50	0.588

Property	Details
Experiments	19828694, 18574028, 9751747
Identification Methods	anti tag coimmunoprecipitation, two hybrid, lex-a dimerization assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 348 Hs			1 593
+	Hs
		798184 KI2L3_HUMAN (1-340): 3.49e-131: 379: 90.32		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		986023 KI2L4_HUMAN (1-345): 2.35e-120: 353: 63.01		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665819 KI2L1_HUMAN (1-348): 1.19e-135: 391: 100.00		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		665820 KI2L3_HUMAN (1-340): 3.49e-131: 379: 90.32		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Mm
		719307 LRB4A_MOUSE (1-335): 1.93e-72: 229: 26.25		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		798232 KI3L1_HUMAN (1-348): 8.24e-64: 210: 30.77		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665921 LIRB4_HUMAN (1-324): 5.2e-81: 255: 29.46		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		616953 KI2L1_HUMAN (1-348): 1.19e-135: 391: 100.00		PTPRD_HUMAN (39-522): 2.1e-115: 379: 26.76
+	Mm
		665991 LRB4A_MOUSE (1-335): 1.93e-72: 229: 26.25		PTN6_MOUSE (6-583): 0: 530: 55.94
+	Hs
		665821 KI3L1_HUMAN (1-348): 8.24e-64: 210: 30.77		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		985972 LAIR1_HUMAN (1-141): 4.25e-36: 134: 23.08		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Mm
		719316 Q8K4V6_MOUSE (29-246): 2.24e-32: 129: 26.67		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Mm
		719293 LIRB3_MOUSE (29-246): 6.27e-31: 125: 26.22		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		532367 CEAM1_HUMAN (14-295): 1.08e-21: 97.6: 13.91		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Mm
		682308 CEAM1_MOUSE (30-338): 2.34e-20: 93.8: 13.98		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		665902 LAIR1_HUMAN (1-141): 4.25e-36: 134: 23.08		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Mm
		665982 LIRB3_MOUSE (29-246): 6.27e-31: 125: 26.22		PTN6_MOUSE (6-583): 0: 530: 55.94
+	Hs
		252776 LIRB3_HUMAN (30-335): 5.08e-24: 104: 23.99		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		616999 LIRB4_HUMAN (1-324): 5.2e-81: 255: 29.46		PTPRD_HUMAN (39-522): 2.1e-115: 379: 26.76
+	Hs
		532361 CEAM1_HUMAN (14-295): 1.08e-21: 97.6: 13.91		PTN6_HUMAN (6-593): 0: 531: 55.27