HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	16712842
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4
Common GO terms	GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 409
+	Hs
		507103 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		UBB_HUMAN (1-79): 2e-32: 123: 30.38
+	Mm
		508974 BRCA1_MOUSE (1-1858): 0: 1394: 55.69		UBC_MOUSE (1-118): 1.79e-32: 131: 21.67
+	Hs
		507296 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		UBB_HUMAN (1-79): 2e-32: 123: 30.38
+	Hs
		931604 TRI39_HUMAN (15-389): 9.31e-67: 238: 12.95		RD23A_HUMAN (1-409): 9.16e-94: 287: 56.72
+	Hs
		1420576 TRIM5_HUMAN (10-339): 5.44e-64: 229: 13.27		UBQL2_HUMAN (1-364): 5.95e-51: 182: 13.68
+	Hs
		1420591 TRIM4_HUMAN (15-377): 9.13e-63: 225: 11.52		UBQL2_HUMAN (1-364): 5.95e-51: 182: 13.68
+	Hs
		507312 TRI11_HUMAN (11-390): 3.27e-74: 258: 11.49		UBB_HUMAN (1-79): 2e-32: 123: 30.38
+	Hs
		1089281 TRI26_HUMAN (12-287): 2.54e-51: 193: 14.53		UBQL2_HUMAN (1-364): 5.95e-51: 182: 13.68
+	Mm
		509100 RO52_MOUSE (14-409): 2.04e-66: 235: 13.15		UBC_MOUSE (1-118): 1.79e-32: 131: 21.67
+	Mm
		508938 RO52_MOUSE (14-409): 2.04e-66: 235: 13.15		UBB_MOUSE (1-79): 1.53e-31: 123: 30.38
+	Hs
		507358 TRIM5_HUMAN (10-339): 5.44e-64: 229: 13.27		UBB_HUMAN (1-79): 2e-32: 123: 30.38
+	Mm
		987290 RO52_MOUSE (14-409): 2.04e-66: 235: 13.15		RS27A_MOUSE (1-90): 2.45e-15: 75: 26.67
+	Mm
		987308 RO52_MOUSE (14-409): 2.04e-66: 235: 13.15		RL40_MOUSE (1-84): 1.43e-15: 74.6: 29.76
+	Hs
		507333 BARD1_HUMAN (13-366): 8.77e-32: 137: 11.98		UBB_HUMAN (1-79): 2e-32: 123: 30.38
+	Hs
		987466 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		RL40_HUMAN (1-91): 3.58e-33: 122: 28.57
+	Mm
		267023 BARD1_MOUSE (13-458): 2.98e-23: 109: 10.89		UBC_MOUSE (1-118): 1.79e-32: 131: 21.67
+	Hs
		987200 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		RS27A_HUMAN (1-90): 2.41e-15: 75: 26.67