HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: SPAG5 (Q96R06)
Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)
Gene: SPAG5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34591612
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007059 - chromosome segregation GO:0016604 - nuclear body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1863 Hs			1 1193
+	Hs
		772651 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH9_HUMAN (208-1187): 1.01e-40: 166: 10.74
+	Hs
		587580 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		DESP_HUMAN (501-1190): 1.25e-18: 94.6: 11.43
+	Hs
		773114 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH10_HUMAN (750-1192): 3.06e-17: 89.9: 14.06
+	Hs
		799241 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH14_HUMAN (449-1088): 6.1e-13: 75.8: 14.74
+	Hs
		799134 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PLEC_HUMAN (462-1139): 9.6e-12: 72: 14.40
+	Hs
		157033 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		CTRO_HUMAN (423-721): 3.13e-10: 66.9: 9.67
+	Hs
		587753 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		DESP_HUMAN (501-1190): 1.25e-18: 94.6: 11.43
+	Hs
		1401152 BARD1_HUMAN (13-366): 8.77e-32: 137: 11.98		SPAG5_HUMAN (1-1193): 2.85e-139: 454: 100.00
+	Hs
		48314 A0AVN2_HUMAN (13-366): 6.19e-32: 137: 11.98		SPAG5_HUMAN (1-1193): 2.85e-139: 454: 100.00
+	Hs
		157686 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		CTRO_HUMAN (423-721): 3.13e-10: 66.9: 9.67
+	Hs
		1141792 MCPH1_HUMAN (1150-1857): 1.33e-95: 331: 14.19		EEA1_HUMAN (712-1190): 2.73e-16: 86.8: 10.12
+	Hs
		773006 TRIM6_HUMAN (10-377): 7.06e-68: 240: 13.54		MYH9_HUMAN (208-1187): 1.01e-40: 166: 10.74
+	Hs
		563033 TRIM6_HUMAN (10-377): 7.06e-68: 240: 13.54		MYH6_HUMAN (189-992): 4.33e-29: 128: 10.29
+	Hs
		556952 TRIM6_HUMAN (10-377): 7.06e-68: 240: 13.54		MYH7_HUMAN (238-962): 3.69e-28: 125: 11.39
+	Hs
		587554 RO52_HUMAN (15-390): 5.97e-69: 243: 12.86		DESP_HUMAN (501-1190): 1.25e-18: 94.6: 11.43
+	Hs
		773270 TRIM6_HUMAN (10-377): 7.06e-68: 240: 13.54		MYH10_HUMAN (750-1192): 3.06e-17: 89.9: 14.06
+	Hs
		623354 RO52_HUMAN (15-390): 5.97e-69: 243: 12.86		PLEC_HUMAN (462-1139): 9.6e-12: 72: 14.40
+	Hs
		157821 TRIM4_HUMAN (15-377): 9.13e-63: 225: 11.52		CTRO_HUMAN (423-721): 3.13e-10: 66.9: 9.67
+	Hs
		773005 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH9_HUMAN (208-1187): 1.01e-40: 166: 10.74
+	Hs
		773269 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH10_HUMAN (750-1192): 3.06e-17: 89.9: 14.06