HitPredict

Interactor 1: UBP5 (P45974)
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)
Gene: USP5

Interactor 2: TRIM8 (Q9BZR9)
E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)
Gene: TRIM8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 858 Hs			1 551
+	Hs
		800631 UBP5_HUMAN (1-858): 0: 842: 100.00		TRI39_HUMAN (6-526): 1.65e-75: 250: 14.67
+	Hs
		800627 UBP5_HUMAN (1-858): 0: 842: 100.00		TRIM5_HUMAN (1-521): 1.5e-74: 246: 14.08
+	Hs
		800600 UBP5_HUMAN (1-858): 0: 842: 100.00		TRIML_HUMAN (2-512): 2.72e-63: 216: 13.09
+	Hs
		800581 UBP5_HUMAN (1-858): 0: 842: 100.00		TRI25_HUMAN (8-365): 1.14e-59: 210: 22.31
+	Hs
		800578 UBP5_HUMAN (1-858): 0: 842: 100.00		TRI26_HUMAN (1-412): 2.24e-59: 207: 16.39
+	Hs
		800611 UBP5_HUMAN (1-858): 0: 842: 100.00		TRI63_HUMAN (2-347): 1.63e-59: 202: 19.67
+	Hs
		800622 UBP5_HUMAN (1-858): 0: 842: 100.00		TRI54_HUMAN (2-347): 4.95e-59: 202: 17.76
+	Hs
		800623 UBP5_HUMAN (1-858): 0: 842: 100.00		TRI55_HUMAN (2-347): 8.15e-53: 190: 19.18
+	Hs
		1273567 UBP13_HUMAN (2-858): 0: 721: 59.47		TRI63_HUMAN (2-347): 1.63e-59: 202: 19.67
+	Hs
		1273576 UBP13_HUMAN (2-858): 0: 721: 59.47		TRI55_HUMAN (2-347): 8.15e-53: 190: 19.18
+	Hs
		1273855 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRIM8_HUMAN (1-551): 4.58e-135: 405: 100.00
+	Hs
		1273788 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRI11_HUMAN (2-522): 2.8e-82: 266: 15.49
+	Hs
		1223388 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRI22_HUMAN (1-524): 1.06e-75: 250: 12.57
+	Hs
		1273766 USP9X_HUMAN (289-758): 2.24e-84: 298: 16.20		TRI33_HUMAN (14-534): 5.05e-61: 220: 14.95
+	Hs
		536961 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRI27_HUMAN (1-531): 9.22e-71: 237: 12.63
+	Hs
		1019375 UBP36_HUMAN (250-817): 9.73e-85: 295: 13.61		TRI26_HUMAN (1-412): 2.24e-59: 207: 16.39
+	Hs
		1273778 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRI63_HUMAN (2-347): 1.63e-59: 202: 19.67
+	Hs
		1273851 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRI54_HUMAN (2-347): 4.95e-59: 202: 17.76
+	Hs
		1273852 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRI55_HUMAN (2-347): 8.15e-53: 190: 19.18
+	Hs
		1273857 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRI31_HUMAN (1-318): 4.16e-42: 158: 19.06